Wireless technique has greatly improved in recent years. Applications in many different field arise quickly. Bio-medical signal wireless sensor system is one of the hottest research targets. The objective of this thesis is to design a wireless interface suitable for bio-medical signals. I adopt on-off keying(OOK)digital modulation in my circuit design. On the other hand, I try to fabricate two set of portable wireless ECG devices. Study the theme can be divided into three parts: In first and second parts, I design a set of OOK transmitters and receivers separately. We will confer how to implement fully monolithic transceivers with complete functions. The transmitters and receivers mentioned above is respected to integrate in the future for bio-medical chip. So I try to display portable wireless ECG devices by fabricating modules in third part.