WAKE透過類胰島素信號通路調節雄果蠅同性間的求偶行為

WAKE Mediates Drosophila Male-Male Courtship Activity through Insulin-Like Signaling Pathway

鄧耀邦(Yao-Bang Deng)

指導教授 ： 傅在峰

國立暨南國際大學/科技學院/應用化學學系生物醫學碩士班/碩士(2019年)

https://doi.org/10.6837/ncnu201900297

摘要

WAKE已證實在黑腹果蠅(Drosophila melanogaster)參與調節生物韻律與穩固睡眠週期，在發育時期也與細胞的不對稱分裂(asymmetric cell division; ACD)有關。本論文進一步確認WAKE在胰島素生成細胞(insulin producing cells; IPCs)參與調控雄性果蠅同性間求偶行為的發生，更證實WAKE功能的缺失是透過胰島素訊息引發雄果蠅同性間求偶行為的發生，後續理解WAKE如何透過胰島素訊息對同性間性反應的調節是一個全新且有趣的方向。

關鍵字

果蠅 ； WAKE ； 胰島素 ； 同性間求偶行為

並列摘要

WAKE is highly important to neurological functions in Drosophila, implicated in circadian and sleep maintenance and it is an essential regulator in asymmetric cell division (ACD) of neuroprecursor cells in developmental stage. In this thesis, we evidenced WAKE deficits in insulin producing cells (IPCs) that prompts inter-male courtship underlie insulin/insulin-like growth factor signaling (IIS) pathway. This is an interesting discover but how IIS induced male to male courtship needs further study.

並列關鍵字

Drosophila ； WAKE ； insulin ； male-male courtship

參考文獻

Agrawal, S., Safarik, S., Dickinson, M., 2014. The relative roles of vision and chemosensation in mate recognition of drosophila melanogaster. J Exp Biol 217 (Pt 15), 2796-805.

Alt, S., Ringo, J., Talyn, B., Bray, W., Dowse, H., 1998. The period gene controls courtship song cycles in drosophila melanogaster. Anim Behav 56 (1), 87-97.

Argue, K.J., Yun, A.J., Neckameyer, W.S., 2013. Early manipulation of juvenile hormone has sexually dimorphic effects on mature adult behavior in drosophila melanogaster. Horm Behav 64 (4), 589-97.

Auer, T.O., Benton, R., 2016. Sexual circuitry in drosophila. Curr Opin Neurobiol 38, 18-26.

Bai, H., Kang, P., Tatar, M., 2012. Drosophila insulin-like peptide-6 (dilp6) expression from fat body extends lifespan and represses secretion of drosophila insulin-like peptide-2 from the brain. Aging Cell 11 (6), 978-85.