This study intends to explore the effects of hotel employees’ regulatory foci on their voice behavior, and simultaneously examines the moderating role of leader-member exchange. Questionnaire survey was conducted in 10 international tourist hotels in Taiwan. Of the returned sample, 479 questionnaires are effective. The result indicates that hotel employees’ promotion focus and prevention focus have positive effects on their voice behavior; prevention focused employees have more voice behavior than promotion focused employees. Also, leader-member exchange can moderate the relationship between regulatory foci and voice behavior. Implications for managers and suggestions for future research are discussed.