以掃頻式光學同調斷層掃瞄協助色素母斑的診斷

陳惠雯

指導教授 ： 郭文娟

國立臺灣師範大學/理學院/光電科技研究所/碩士(2009年)

摘要

光學同調斷層掃描（OCT）為一種非侵入式的醫學斷層掃描造影，它具有穿透深度為1-2mm以及高解析度（2-20m）的優點；在皮膚醫學相關的疾病診斷上已被運用於診斷基底細胞惡性腫瘤、鱗狀細胞惡性腫瘤、刺青、熱帶疾病（皮膚寄生蟲爬行症）、牛皮癬及接觸性皮膚炎等方面。而在皮膚惡性腫瘤當中，以黑色素腫瘤擁有最高致死率，其原因是由於惡性黑色素細胞極易快速的不正常增生且不易被察覺。由於黑色素細胞一般存在於皮膚表皮層的底部，可聚集形成色素母斑，也就是俗稱的痣，為良性，本計畫擬針對色素母斑進行形態與光學參數的量測，提供可定量及參考性的參數，希望能對協助臨床上皮膚惡性黑色素腫瘤之早期診斷有所貢獻。

關鍵字

色素母斑 ； 惡性黑色素細胞 ； 掃瞄式光源之光學同調斷層攝影系統 ； 散射係數

並列摘要

Optical coherence tomography (OCT) is a noninvasive imaging technique in medical images. It has several advantages such as long penetration depth (~ 1-2 mm) and high axial resolution (~ 2-20μm). OCT technique has been applied in dermatology medicine including basal cell carcinoma, actinic keratosis, tattoo, tropical disease (cutaneoys larva migrans), psoriasis, contact dermatitis and so on. In skin cancer, malignant melanoma is the common cause of mortality, which is due to the melanocytes is prone to easily abnormal proliferate and hard to find. Generally, most Melanocytes locate at the button layer of the skin epidermis and may aggregate to form the pigment nevi. In this study, we will measure the pigment nevi’s morphology and optical property. The results may provide quantitative and reference parameters that will contribute to the early diagnosis of malignant melanoma in skin.

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