Drosophila angiotensin converting enzyme-related (Acer) 基因於果蠅心臟發育之功能探討

Function of Angiotensin converting enzyme -related gene in Heart development of Drosophila melanogaster

李靜怡(Jing-Yi Li)

指導教授 ： 蘇銘燦

國立臺灣師範大學/理學院/生命科學研究所/碩士(2003年)

摘要

無資料

關鍵字

心臟發育 ； 果蠅 ； HASH(0xd57e01c) ； HASH(0xd57e094) ； HASH(0xd57e10c) ； HASH(0xd57e184) ； HASH(0xd57eb30)

並列摘要

Heart of Drosophila consists of 104 cells which are classified into different groups according the specific cell markers and functions. As its structure is relative simple, this makes Drosophila is one of the most excellent models to study the cardiogenesis of animals. In this study we plant to study the function of acer in heart development using Drosophila as a model system. Acer is a metallopeptidase. Previous studies suggested that it may function in development heart. Nevertheless, its role in heart morphogenesis has not been characterized in detail. in situ hybridization demonstrates that acer is expressed exclusively in heart of Drosophila (dorsal vessel). Immunocytochemistry stainings using different heart-specific markers, such as tinman, odd and eve, have revealed that cardial and pericardial cells are missing or misplaced in acer mutant embryos. By contrast, overexpression of Acer results in overproduction of cardial and pericardial cells. As the heart phenotypes of acer were similar to that of tinman and pnr, this indicate that acer, tinman and pnr act in the same pathway during heart morphorgenesis in flies. Preliminary studies demonstrated that acer may interact with tin and pnr. Further studies are needed to demonstrate if acer acts in concert with tin and pnr or function along to specify different cardial cell types.

並列關鍵字

heart development ； cardiogenesis ； Drosophila ； acer ； ACE ； angiotensin converting enzyme ； angiotensin converting enzyme-related

參考文獻

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