非血基質鐵三價超氧化物與過氧化物之合成與反應性探討

Synthesis and Reactivity of Non-Heme Iron(III) Superoxo and Hydroperoxo Complexes

吳肇洋(Wu Jhao-Yang)

指導教授 ： 李位仁

國立臺灣師範大學/理學院/化學系/碩士(2018年)

https://doi.org/10.6345/THE.NTNU.DC.044.2018.B05

摘要

在生物體中，細胞色素P450催化過程中推測有鐵超氧化物、鐵過氧化物和鐵過氧氫化物之中間體生成，其中鐵超氧化物為重要的中間體。實驗室先前的研究，利用FeII(BDPP) 於193 K下與氧氣反應生成鐵超氧化物，再經奪氫反應生成鐵過氧氫化物。在本次研究中，我們使用較穩定的FeIII(BDPBrP)(OO˙)重複先前的實驗，也利用鐵過氧氫化物與酸性受質反應，由紫外光可見光光譜我們推測生成鐵三價物質與過氧化氫。另外，我們也嘗試於193 K下加入超氧化鉀反應，生成之產物其紫外光可見光光譜得到與鐵過氧氫化物之光譜類似的樣式，此產物與酸性受質反應也與鐵過氧氫化物有類似的反應性。

關鍵字

鐵過氧氫化物 ； 鐵過氧化物

並列摘要

The catalytic process of cytochrome P450 in organism is presumed to produce iron superoxo and iron peroxo intermediates, and iron superoxo species is the first intermediate. Previously, we have developed FeII(BDPP) which can activate oxygen at 193 K to generate iron superoxo complex. The iron superoxo complex reacted to form iron hydroperoxo species. In this study, we not only repeat previous experiments by using a more stable complex of FeIII(BDPBrP)(OO˙) species, and allow iron hydroperoxo species to react with acidic substrates. From UV-vis spectra, we propose that the formation of iron(III) species and hydrogen peroxide. In addition, we attempt to add potassium superoxide with cryptand at 193 K. The UV-vis spectrum of the resulting solution was similar to that of the iron hydroperoxo spcies. The reaction of the product with the acidic substrate was also similar to the iron hydroperoxo species.

並列關鍵字

iron hydroperoxo ； iron peroxo

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