使用海洛因之C型肝炎感染者在美沙冬與C肝治療之順從性研究

本研究目的是了解藥癮C型肝炎感染者，在美沙冬維持療法與C型肝炎治療之情形，並探討美沙冬維持療法是否提升C型肝炎治療之順從性。本研究透過衛生福利部「替代治療作業管理系統」及醫院所屬「醫療管理系統」之次級資料庫進行分析。針對2017-2020年本國籍，於中部某地區教學醫院曾參與美沙冬維持治療合併C型肝炎感染者，藉由卡方、t-test、複迴歸分析背景變項與治療的關係；而美沙冬參與天數、美沙冬服藥順從性、C型肝炎全口服直接作用抗病毒藥物(directly acting antivirals, DAAs)參與天數，進行相關分析，分析美沙冬參與天數與美沙冬及C型肝炎服藥順從性關係。本研究共分析169人，結果顯示，在患者第一次加入美沙冬維持治療時，其服藥順從性與婚姻狀態有顯著差異；患者是否有愛滋在第一次加入美沙冬維持治療時有差異；美沙冬維持治療服藥順從性是否提升C型肝炎治療順從性則無顯著差異。研究建議應鼓勵藥癮者C型肝炎感染者治療C肝，相關醫療人員亦需積極治療藥癮者C型肝炎患者，讓患者可以在治療藥癮的同時C肝也被治癒。

關鍵字

海洛因； C型肝炎；美沙冬維持療法；服藥順從性

並列摘要

In this study is examine whether methadone maintenance therapy(MMT) increased hepatitis C therapy adherence among a cohort of hepatitis C people who inject drugs (PWIDs). This study analyzed the secondary database. There were 169 PWIDs participants who accessed MMT from 2007-2020 and participated the hepatitis C treatment in the same hospital.We used the Chi-Squared Test, t-test and multiple regression analysis to examined relationship between demographic variables and hepatitis C treatment and medication adherence of methadone. In this study showed that the adherence of the patients with methadone treatment and the marital status were significantly different when they first joined the methadone maintenance treatment; the patients had AIDS were significantly difference when they first joined methadone maintenance therapy; there was no significant difference between the adherence of methadone treatment and the adherence of treatment with hepatitis C. The results of this study suggested that health staffs should encourage PWIDs with hepatitis C treat hepatitis C positively.