Influenza A (H1N1) infection is associated with intimate exposure to livestock. Personality and perceptions of risk can modify behaviors, influencing actual exposure. This study examined the relations between personality, risky perception, and coping behaviors to epidemic prevention among 244 households. The hypothesis was that personality would affect coping behaviors to epidemic prevention in two ways: directly, irrespective of risky perception, and indirectly, through the effects of personality on risk perception. In Structure Equation Modeling model we found the expected direct and indirect effects. The personality dimensions of Agreeableness and Conscientiousness had positive direct effects on coping behavior. However, risk perception mediates the effect of personality on coping behavior. This study also utilizes multi-group structure equation modeling to examine measurement equivalence of different demographic variables. Findings reveal a lack of measurement equivalence between the age, strength of epidemic prevention and veterinarian employment. Implications of the pattern of results for future research are discussed.