溫度敏感型高分子之製作及其功能評估

本研究將羧酸基團經聚合反應轉移至NIPAAm而形成PNIPAAm-COOH，並將之與聚乙二醇及二苯基甲烷二異氰酸鹽製備出具有溫度敏感性之聚胺酯薄膜(TSPU)，並探討PNIPAAm-COOH之含量對TSPU性質之影響。文中發現，TSPU之膨潤率、去膨潤率及擴散係數，會隨著PNIPAAm-COOH含量的增加而提高，但其機械性質與熱穩定性，並不會隨著PNIPAAm-COOH含量的增加而改變。由紅外光譜動態升溫實驗結果獲知，TSPU分子鏈間的氫鍵強度在最低臨界溶液溫度點附近會隨著溫度上升而減弱。為了更進一步瞭解TSPU作為敷材時，是否會對人類皮膚產生毒性，我們以細胞存活測定來評估TSPU對人類上皮細胞的影響。而當溫度超過其最低臨界溶液溫度時(37度)，TSPU之水氣穿透率為2500g/m2day左右，這已達理想敷材之水準。

關鍵字

溫度敏感；智能敷材；異丙基丙烯醯胺；保水力；細胞毒性評估。

並列摘要

This object was to develop thermosensitive polyurethane(TSPU) by polymerization with polyethylene glycol, 4, 4’-methylenediphenyl diisocyanate and N-isopropylacrylamide (NIPAAm). NIPAAm has been synthesized first by grafting PNIPAAm-COOH with a single carboxyl group before polymerization. The influence of the content of PNIPAAm-COOH on the properties of TSPU was investigated. The results indicated that the swelling ratio, deswelling ratio and diffusion coefficient of TSPUs were increased with the content of PNIPAAm-COOH, but their mechanical and thermal properties were not changed significantly as the concentration of PNIPAAm-COOH increased. The hydrogen bond was weakened between molecular chains of TSPU as temperature was increased around the lower critical solution temperature ranges, which was evidenced by in-situ temperature-dependent Fourier Transform infrared spectrometer study. The cytotoxicity evaluation shows that the TSPU had no toxicity for human epithelium. In addition, the water vapor transmission rate of TSPU was about 2500g/m2day at 37。C, which is an ideal WVTR for dressing.

並列關鍵字

Thermosensitive polyurethane (TSPU) ； N-isopropylacrylamide ； lower critical solution temperature ； in-situ temperature-dependent Fourier Transform infrared spectrometer, cytotoxicity evaluation.

參考文獻

[1]T. T. Reddy, A. Kano, A. Maruyama, M. Hadano, A., 2008, Takahara, “Thermosensitive Transparent Semi-Interpenetrating Polymer Networks for Wound Dressing and Cell Adhesion Control”, Biomacromolecules, Vol. 9, pp. 1313-1321.

[2]J. M. Yang, S. J. Yang, H. T. Lin, T. H. Wu, H. J. Chen, 2008, “Chitosan containing PU/Poyly(NIPAAm) thermosensitive membrane for wound dressing”, Materials Science and Engineering C, Vol. 28, pp. 150-159.

[3]S. Tanodekaew, M. Prasitsilp, S. Swasdison, 2004, “Preparation of acrylic grafted chitin for wound dressing application”, Biomaterials, Vol. 25, pp. 1453-1460.

[4]F. L. Mi, S. S. Shyu, Y. B. Wu, S. T. Lee, 2001, “Fabrication and characterization of a sponge-like asymmetric chitosan membrane as a wound dressing”, Biomaterials, Vol. 22, pp. 165-173.

[5]X. Jiang, J. Li, M. Ding, H. Tan, Q. Ling, Y. Zhong, Q. Fu, 2007, “Synthesis and degradation of nontoxic biodegradable waterborne polyurethanes elastomer with poly(?-caprolactone) and poly(ethylene glycol) as soft segment”, European Polymer Journal, Vol. 43, pp. 1838-1846.

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溫度敏感型高分子之製作及其功能評估

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