以藥物分子為模板製備電化學感測器及其分子辨識之研究

Study of Molecular Recognition for Electrochemical Sensor Based on Drug Molecular Imprinting

陳柏誠(Bo-Cheng Chen)

指導教授 ： 黃英邦

國立虎尾科技大學/工程學院/材料科學與綠色能源工程研究所/碩士(2010年)

摘要

本研究是以導電高分子聚?咯（PPy）作為甲基橙、抗生素-盤尼西林及五胜?等三種藥物分子模板，在草酸?咯單體水溶液中分別添加甲基橙、抗生素-盤尼西林及五胜?等三種藥物分子，以循環伏安法(Cyclic Voltammetry)電化學聚合於白金電極上，分別製作各種具有不同。
將不同藥物分子感測電極置於含有不同濃度藥物分子之待測溶液中，分別以循環伏安法及交流阻抗法進行分析感測電極對於分子之辨識行為。由循環伏安法實驗結果顯示：含有甲基橙濃度在40 ppm具有最高之氧化電流峰值，而抗生素-盤尼西林及五胜?則在100 ppm有最高之氧化電流峰值。由交流阻抗法實驗結果顯示：甲基橙、抗生素-盤尼西林及五胜?有明顯的電容及電阻現象以及有如Warburg形態的擴散行為。經由循環伏安法與交流阻抗分析，本研究製作的電極非常適合應用於藥物分子的感測器。

關鍵字

電化學感測器 ； 模板 ； 循環伏安法 ； 交流阻抗分析

並列摘要

In this study, an electrochemical sensor based on drug molecularly imprinted polypyrrole was prepared by employing three different agents, namely, Methyl orange, Penicillin G and 5-peptide (5-amino acid) in pyrrole monomer containing oxalic acid solution using cyclic voltammetry electrochemical polymerization on Pt electrode, respectively.
Recognition behaviors of electrochemical sensors in solutions with three different agents were investigated by cyclic voltammetry technique and electrochemical impedance spectroscopy (EIS) methods. From the cyclic voltammogram of the electrode, the highest oxidation current peak at 40 ppm concentrations was detected for Methyl orange solution. However, the highest oxidation current peaks were also observed for Penicillin G and 5-peptide (5-amino acid) solutions at 100 ppm concentrations. From the impedance spectra, the sensors were found to exhibit a capacitance and resistance phenomenon, and Warburg-type diffusion behaviors were also observed. Through the cyclic voltammetry technique and electrochemical impedance spectroscopy analysis, result showed that the prepared electrode was suitable for drug sensor applications.

並列關鍵字

Electrochemical sensor ； Molecular imprinting ； Polypyrrole ； Electrochemical impedance spectroscopy

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