- 學位論文
混合自組裝膜抗菌抗污性研究
Anti-Bacterial and Anti-Fouling Properties of the Mixed Self-Assembled Monolayers Study
摘要
隨著時代進步疏水性薄膜因為具有抗水與抗霧及防止污染特性已被廣泛的應用。自組裝薄膜(SAMs)具有類似有效控制材料的表面特性，並且製作過程簡單與高穩定性，利用自發性的單分子膜吸附在基材上形成規則排列且緊密的自組裝薄膜，近年來已經廣泛的應用在很多的領域，如生醫應用、光學、電子機械、機械工程等等。 本文建立以自組裝薄膜技術達成抗菌抗污之表面薄膜，利用有機矽烷類的自組裝薄膜透過混合的抗菌藥劑在光學鏡片上形成自組裝薄膜的親疏水性、組成情形、透光率、表面清潔度及接觸角度的性能，再利用以上條件研究出最佳的混合抗菌自組裝薄膜。實驗中準備了九種自組裝膜分別為ODS、 OTS、ODS加濃度10 %抗菌藥劑、OTS加濃度10 %抗菌藥劑、ODS加濃度50%抗菌藥劑、OTS加濃度50 %抗菌藥劑，並分為表面經電漿界面強化處理與未處理兩組，在不同溫度、震盪頻率、轉速及浸泡時間來以及TEOS加ODS、TEOS加ODS在加上抗菌10 %及50 %，在不同轉速下之自組裝薄膜進行實驗，研究結果發現，自組裝薄膜對光學鏡片之透光性質的影響極微小。在ODS和OTS及加上抗菌10 %及50 %之六種自組裝薄膜的接觸角實驗中，反應時間12小時，溫度為60 ℃時有最佳之效果，和TEOS加ODS及加上抗菌10 %及50 %之三種自組裝薄膜，最大角度為TEOS加ODS，反應時間12小時、溫度在40 ℃、轉速為200 rpm時，接觸角度可達160°以上。鏡片與自組裝薄膜的界面強化處理，可發現ODS自組裝薄膜、ODS混合濃度50 %抗菌藥劑的臨界負荷可以提高51.1 %、54.46 %。在黏附力的分析結果顯示TEOS加ODS有最佳的黏附力，但是各種藥劑再加入抗菌後，不管是在黏附力量還是粗糙度及接觸角度上，皆有下降的趨勢，由ESCA光電子能譜儀實驗數據中可得知九種的自組裝薄膜皆於溶液中進行水解並鍵結形成薄膜在基材表面上。因此總結以上結果，由ODS+Anti50 %的混合抗菌自組裝薄膜其效果最好，而TEOS+ODS則具有最佳的疏水性接觸角與適宜抗菌性，但仍需要改善其自組裝薄膜之表面清潔度。
並列摘要
With the progress of the times a hydrophobic film because of the water-resistant and anti-fog and prevent pollution characteristics has been widely used. Similar to the effective control of surface properties of the material self-assembled thin films (SAMs), and the production process is simple and high stability, spontaneous monolayers adsorbed on the substrate to form a self-assembly film of ordered and closely in recent years has been widely applications in many fields such as biomedical applications, optical, electrical machinery, mechanical engineering and so on. Established antimicrobial fouling of the surface film to reach a self-assembled thin-film technology, the use of organic silane class of self-assembled film formed on the optical lens through the mix of antimicrobial pharmaceutical hydrophobic self-assembled films, composed of the case, transmittance, surface cleanlinessand contact angle performance, re-use of the above conditions to work out the best mixed antibacterial self-assembly film. Prepared nine kinds of self-assembled monolayers of ODS OTS, ODS increase the concentration of 10% anti-bacterial pharmaceutical experiments, the OTS added concentration of 10% anti-bacterial pharmaceutical ODS increase the concentration of 50 % antibacterial Pharmacy, the OTS added concentration of 50 % anti-bacterial pharmaceutical, and is divided into strengthen the treatment and untreated groups, surface plasma interface at different temperatures, the oscillation frequency, speed and soaking time and TEOS plus ODS, TEOS plus ODS plus antibacterial 10 % and 50 %, at different speeds, self-assembly film experiment, the study found that tiny self-assembled film on the nature of the transmittance of the optical lens. The best effect, and TEOS plus ODS together with antimicrobial 10 antimicrobial 10 % and 50 % of the six kinds of ODS and OTS, and coupled with self-assembled films contact angle experiments, reaction time 12 hours, temperature 60 ° C 10 % and 50 % of the three kinds of self-assembled film, the maximum angle of the TEOS plus ODS 12 hours of reaction time, temperature at 40 ℃, the speed of 200 rpm, the contact angle up to 160 ° or more. Lens and self-assembled film interface strengthening treatment, can be found in the ODS self-assembled film, the critical load of ODS mixing concentration of 50 % of antimicrobial agents can be increased by 51.1 %, 54.46 %. The analysis results show that the adhesion TEOS plus ODS have the best adhesion, but after a variety of pharmaceutical re-joined the anti-bacterial, whether it is on the adhesion strength, roughness and contact angle, there are a downward trend by ESCA photoelectron spectrometernine kinds of experimental data that can be learned are self-assembled film was hydrolyzed in solution and the formation of bonding film on the substrate surface. Therefore summarize the results above, self-assembled film of ODS + Anti50 % mixed antibacterial best TEOS + ODS hydrophobic contact angle with appropriate antimicrobial, but still needs to improve its self-assembled film of surface cleaning degrees.