親水性的褐藻糖與疏水性的蝦紅素製備奈米載體應用於缺血性中風大鼠模型療效的評估

Study on the nanoparticle using hydrophilic fucoidan and hydrophobic astaxanthin to evaluate treatment effect through the ischemic stroke model in rat

陳瑩庭(Ying-Ting Chen)

指導教授 ： 陳三元

國立交通大學/工學院/奈米科技研究所/碩士(2018年)

摘要

無資料

關鍵字

褐藻醣 ； 蝦紅素 ； 奈米載體 ； 中風 ； 抗發炎 ； 神經保護

並列摘要

無資料

並列關鍵字

fucoidan ； astaxanthin ； nanoparticle ； stroke ； anti-inflammatory ； neuroprotective

參考文獻

[1] V. L. Feigin, C. M. M. Lawes, D. A. Bennett, S. L. Barker-Collo, and V. Parag, "Worldwide stroke incidence and early case fatality reported in 56 population-based studies: a systematic review," The Lancet Neurology, vol. 8, no. 4, pp. 355-369, 2009.

[2] P. T. Keith W. Muird, Naveed Sattarb and Elizabeth Warburtonc, "Inflammation and ischaemic stroke," Current Opinion in Neurology, vol. 20, pp. 334–342, 2007.

[3] a. Li-xia Zhao, b,# An-chang Liu,b,# Shu-wen Yu,c Zeng-xin Wang,d Xiao-qian Lin,a Guang-xi Zhai,a and Qing-zhu Zhang*,a, "The Permeability of Puerarin Loaded Poly(butylcyanoacrylate) Nanoparticles Coated with Polysorbate 80 on the Blood–Brain Barrier and Its Protective Effect against Cerebral Ischemia/Reperfusion Injury," Biol. Pharm. Bull, vol. 36, no. 8, pp. 1263–1270, 2013.

[4] P. M. Kidd, "Integrated Brain Restoration after Ischemic Stroke – Medical Management, Risk Factors, Nutrients, and other Interventions for Managing Inflammation and Enhancing Brain Plasticity.," Alternative Medicine Review, vol. 14, no. 1, pp. 14-35, 2009.

[5] J. T. C. a. P. Puttfarcken, "Oxidative Stress, Glutamate, and Neurodegenerative Disorders," Science, vol. 262, pp. 689-695, 1993.