雙藥型奈米幾丁聚醣於肺癌治療及應用於功能性貼片之設計開發及特性分析

Design of Dual-drug Chitosan-based Nanotherapeutic system for Anti-lung cancer Treatment and Its Use for Therapeutic Patch Development

莊惠晴(Hui-Ching Chaung)

指導教授 ： 劉典謨

國立交通大學/工學院/材料科學與工程系所/碩士(2019年)

摘要

無資料

關鍵字

兩親性幾丁聚醣 ； 順鉑 ； 去甲氧基薑黃素 ； 功能性貼片

並列摘要

無資料

並列關鍵字

carboxymethyl-hexanoyl chitosan ； cisplatin ； demethoxycurcumin ； therapeutic patch

參考文獻

1. Jamieson, E.R. and S.J. Lippard, Structure, recognition, and processing of cisplatin− DNA adducts. Chemical reviews, 1999. 99(9): p. 2467-2498.

2. Launay-Vacher, V., et al., Prevention of cisplatin nephrotoxicity: state of the art and recommendations from the European Society of Clinical Pharmacy Special Interest Group on Cancer Care. Cancer chemotherapy and pharmacology, 2008. 61(6): p. 903-909.

3. Kumari, A., S.K. Yadav, and S.C. Yadav, Biodegradable polymeric nanoparticles based drug delivery systems. Colloids and surfaces B: Biointerfaces, 2010. 75(1): p. 1-18.

4. Cho, K., et al., Therapeutic nanoparticles for drug delivery in cancer. Clinical cancer research, 2008. 14(5): p. 1310-1316.

5. Scarano, W., P. De Souza, and M.H. Stenzel, Dual-drug delivery of curcumin and platinum drugs in polymeric micelles enhances the synergistic effects: a double act for the treatment of multidrug-resistant cancer. Biomaterials science, 2015. 3(1): p. 163-174.