Manufacturing scheduling in semiconductor wafer fabs is a sophisticated and hard problem. This thesis aims to optimize throughput, mean flow time and mean weighted tardiness simul-taneously subject to the presence of the sequence-dependent setup time and common deadlineconstraints. A new composite dispatching rule is proposed in this study. Different from the tra-ditional elementary dispatching rules like SPT and FIFO, the proposed composite dispatchingrule is composed of elementary rules and associated with the relative importance indicators. TheNSGA-II-based simulation is adopted to perform relative importance optimization. Then DataEnvelopment Analysis is applied to reduce the number of Pareto optimal solutions. The experi-ments on test instances show thathe proposed composite rule has better overall performance thanthe elementary rules. We also built a web site as a simplified decision support system (DSS) todemonstrate our results.