This thesis is to study the binding of curcumin to unsaturated lipid membrane, and the effect of light-inducing degradation on curcumin binding to membrane. We use isothermal titration calorimetry (ITC) to measure the binding free energy, the binding enthalpy and the binding entropy for understanding the thermodynamics of binding process. The result reveals that, the curcumin binding to the unsaturated lipid membrane is an exothermic reaction, and without any external force , it reacts spontaneously. Moreover, we found that the curcumin''s result of hydrolysis has neither binding heat nor effect on the process of intact curcumin binding to membrane.