Currently, injection molding is the primacy method for the manufacture of plastic optical lens. Precise optical components require high accuracy in both geometry and optical specifications. Thus, high quality of the manufacturing process should be provided for producing high-quality optical lenses. This study integrates techniques of mold flow analysis and reverse engineering, and uses these techniques to perform injection molding simulation and error analysis of optical lenses. Also, the advantages of mold flow analysis and reverse engineering are investigated. Traditionally, engineer’s experience is very important in injection molding. This study employs mold flow analysis to analysis parameters of injection molding for improving the quality of the finished parts, and applied reverse engineering to judge the error source for providing the guidance for part improvement. Finally, this study employs actual mold design and manufacturing to demonstrate the manufacturing feasibility of producing optical lenses.