視網膜血管樹重建

Retinal Vascular Tree Reconstruction with Anatomical Realism

林凱舜(Lin Kai-Shun)

指導教授 ： 蔡佳玲 ； 林維暘

國立中正大學/工學院/資訊工程學系/博士(2012年)

摘要

為了能夠實現具有解剖學意義的自動分析及視網膜血管重建，本論文提出並分析一種演算法，結合視網膜血管分割及視網膜血管的分類，所提出的方法目的是重見血管樹的幾何架構並有解剖學上的意義，在臨床研究和診斷上，異常的視網膜動脈或靜脈可以被顯現出來。隨著視網膜血管架構的認知，一個分析視網膜血管樹自動化計算的框架被我們提出。
在重建視網膜血管樹方面，血管的片段分類是使用擴展卡爾曼濾波器，卡爾曼濾波器考慮到血管的連續性，特別是在分叉處或交叉點的曲率、寬度和強度的變化。在一個交叉點，所提出的方法利用最低成本的匹配算法來解決由於追蹤血管分組的衝突。系統訓練使用從二十張DRIVE影像資料庫，其餘二十張影像作為測試用。該影像資料庫混合包含正常和有病變的影像。此外我們也使用六組包含病變的螢光造影圖像序列在我們的研究中。最後，我們發展了一種自動的方法來衡量和量化的幾何和拓樸性質的視網膜血管針對視網膜影像。根據實驗結果，所提出的方法是有效的應用在相關議題。在未來，我們將重點放在分組的正確性，提高了系統的臨床實用性。

關鍵字

血管樹 ； 剖學的意義 ； 交叉點 ； 重建

並列摘要

Motivated by the goals of automatically analyzing vascular trees and reconstructing retinal vascular trees with anatomical realism, this thesis presents and analyses an algorithm that combines vessel segmentation and grouping of the extracted vessel segments. The proposed method aims to restore the topology of the vascular trees with anatomical realism for clinical studies and diagnosis of retinal vascular diseases, which manifest abnormalities in either venous and/or arterial vascular systems. With the knowledge of the vascular trees, an automated computational framework for retinal vascular tree and analysis is presented in this work.
In reconstruction vascular trees, vessel segments are grouped using extended Kalman filter which takes into account continuities in curvature, width, and intensity changes at the bifurcation or crossover point. At a junction, the proposed method applies the minimum-cost matching algorithm to resolve the conflict in grouping due to error in tracing. The system was trained with twenty images from the DRIVE dataset, and tested using the remaining twenty images. The dataset contained a mixture of normal and pathological images. In addition, six pathological fluorescein angiogram sequences were also included in this study. Finally, we have also developed an automatic method to measure and quantify the geometrical and topological properties of retinal blood vessels from fundus retinal images. According to the experimental results, the proposed approaches are indeed effective in relative topics. In the future, we will focus on the correctness of grouping and improve the clinical usability of the system.

並列關鍵字

Vascular tree ； Anatomical significance ； Branch point ； Reconstruction

參考文獻

thesis, National Chung Cheng University, 2007.

Imaging, Medical Image Processing and Analysis, volume 2, chapter

S. Thom. Quantification of topological changes in retinal vascular architecture

applications and potential. Progress in retinal and eye research, 25:99–127,

[4] Helena M. Pakter, Elton Ferlin, Sandra C. Fuchs, Marcelo K. Maestri, Ruy S.