- 學位論文
Organocatalytic One-pot Asymmetric Multistep Multicomponent Synthesis of Functionalized Cyclohepta[b]indoles
Organocatalytic One-pot Asymmetric Multistep Multicomponent Synthesis of Functionalized Cyclohepta[b]indoles
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摘要
本研究利用丙二腈衍生物與α、β-不飽和醛類藉由不對稱有機催化試劑進行Michael 反應，接著再與吲哚化合物利用布朗斯特酸的催化下進行分子內的Friedel-Crafts烷基化反應，在一鍋化的策略下，可合成具有七員環骨架的環庚并[b]吲哚衍生物，且具有高鏡像選擇性及很好的產率，也利用X-ray單晶繞射分析決定出其絕對立體組態。
關鍵字
無資料並列摘要
A highly efficient diastereoselective and enantioselective one-pot multicomponent multistep asymmetric synthesis of cyclohepta[b]indoles was developed. By using the commercially available secondary amine and the Brønsted acid as the catalysts under mild reaction conditions, an efficient construction of the seven-membered carbocycles was achieved.
並列關鍵字
Cyclohepta[b]indoles參考文獻
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