球結膜微循環的特徵擷取

Feature Extraction on Conjunctiva Microcirculation Imaging

劉允中(Yun-Chung Liu)

指導教授 ： 劉偉名

國立中正大學/工學院/資訊工程學系/碩士(2014年)

摘要

微循環是人體循環系統中的基礎單位。微循環除了運送養料和帶走廢物之外，還有一個重要的功能就是負起全身各個組織細胞之間的溝通作用。因此，微循環在保證人體組織細胞的正常代謝和生命活動方面有重要的意義。
自1950年開始，觀測微循環被視為是一種非侵入性診斷技術。研究顯示微循環血管的管絆與流速變化對應著某些疾病的徵兆。藉由觀察微循環的各項指標，可得知人體所發出的生理訊息，如血管扭曲度(vessel tortuosity)、血管分佈密度(distribution density) 、碎形維度(Fractal dimension)、形態分佈(Morphological vascularity)、血管直徑(vessel diameter)和血流速度(flow velocity)等。對疾病預測及療效的判定有其參考價值。
我們的動機就是提出一套有效且即時的量化分析方法，搭配後續的特徵分析，方便使用者即時觀看球結膜血管異常程度，有助於分析與量化病患的微循環系統功能，協助醫師判斷病情。

關鍵字

血液流速 ； 血管直徑 ； 扭曲度 ； 球結膜微循環 ； 血管追蹤

並列摘要

Microcirculation is the basic unit in human circulatory system. Except being responsible for transporting nutrients and wastes, another important role of microcirculation is in communication with various body tissues. Therefore, it is very important in ensuring normal metabolic activities of human life.
Since 1950, observing the microcirculation is considered as a non-invasive diagnostic technique. Research shows that vessel morphometry and blood flow velocity could correspond to the signs of some diseases. By observing the feature of microvasculature we can learn physiological states of the subject, such as vessel tortuosity, distribution density, fractal dimension, morphological vascularity, vessel diameter, flow velocity and so on. These features have clinical values in forecasting the risk of diseases or evaluating the efficacy of treatments.
Our motivation is to propose an effective and real-time quantitative analysis system, with subsequent feature analysis and result output interface for observing the abnormalities on conjunctiva vasculature in real time. In near future the system can allow the users to analyze and quantify someone’s conjunctiva microcirculation and moreover to help the doctors to perform diagnosis.

並列關鍵字

Vessel diameter ； Tortuosity ； Conjunctiva microcirculation ； Flow velocity ； Vessel tracking

參考文獻

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