以溶膠-凝膠法製備介孔CaO-B2O3-SiO2生醫玻璃

Preparation of mesoporous CaO-B2O3-SiO2 bioactive glass by sol-gel method

黃奕霖(Yi Lin Huang)

指導教授 ： 張莉毓

國立屏東科技大學/工學院/機械工程系所/碩士(2010年)

https://doi.org/10.6346/NPUST.2010.00146

摘要

為了改善植入後的生醫玻璃與骨組織之間的生物相容性，必須使植入物表面沉澱出氫氧基磷灰石層。氫氧基磷灰石層的沉積速率與效果取決於生醫玻璃的結構。介孔材料由於具有較高的比表面積和孔體積之特性，因而具有遠高於普通生醫玻璃材料的體外生物活性。
本研究以非離子型界面活性劑為天然有機模板，四乙矽酸鹽、硝酸鈣和硼酸三丁酯為反應物，利用溶膠-凝膠法製備高比表面積之介孔CaO-B2O3-SiO2生醫玻璃。以熱重分析、X-ray 繞射分析、穿透式電子顯微鏡及氮氣吸附/脫附曲線分析該材料之微結構及比表面積
藉由TGA分析可知於空氣氣氛下煆燒至400℃即可完全移除界面活性劑形成介孔結構。樣品經400 ~ 700 ℃煆燒3小時後，由XRD分析結果顯示出20~30°之間有一較寬的繞射峰，此為典型之玻璃特徵。經由氮氣吸附/脫附曲線分析得知，煆燒溫度600 ºC，Ca/B比例為2:2，使用三嵌段兩性共聚物F108合成之介孔生醫玻璃，其平均孔徑為62.48 Å，比表面積為231.52 m2/g 。實驗結果表示此參數條件下之介孔CaO-B2O3-SiO2生醫玻璃於模擬體液中浸泡4小時後，已開始生成氫氧基磷灰石相。

關鍵字

氫氧基磷灰石 ； 生醫玻璃 ； 溶膠–凝膠法 ； 介孔材料

並列摘要

In order to improve the biocompatibility between the implant and the bone tissue, a biologically active hydroxyapatite layer is formed at the implant-tissue interface. The deposition rate and performance of the hydroxyapatite layer was dependent on the structure of bioglass. Mesoporous bioglasses materials have received much interest because of their high specific surface area and pore volume, and exhibit better in vitro bone forming bioactivity compared to conventional bioglasses.
In this study, mesoporous CaO-B2O3-SiO2 bioactive glass with high specific surface area was prepared by sol-gel process and the synthesis was accomplished by using nonionic surfactant (block copolymer) as the template, tetraethyl orthosilicate, calcium nitrate tetrahydrate and tributyl borate as the inorganic precursors. TGA, XRD, TEM and N2 adsorption-desorption isotherms were used to characterize the microstructure of the samples.
TGA analysis showed that the calcination in air at temperature above 400℃ was needed to remove the surfactant completely from the mesopores. A broad band between 20 and 30o can be clearly noted in XRD pattern of mesoporous bioactive glass. It can be seen that after being calcined at 400～700℃ for 3 h the sample almost has an amorphous state, which is indicative of the internal disorder and glassy nature of this material. By the nitrogen absorption / desorption analysis found that the calcination temperature 600 ºC, Ca/B ratio of 2:2, the use of triblock copolymer synthesis of mesoporous bioactive glass was informed that the average diameter of 62.48 Å, specific surface area of 231.52 m2/g. The results reveales that a hydroxyapatite layer started to form on the surface in 4 hr after mesoporous CaO-B2O3-SiO2 mesoporous bioactive glass was immersing in simulated body fluid.

並列關鍵字

hydroxyapatite ； mesoporous bioactive glass ； sol-gel method ； mesoporous material

參考文獻

21. 陳鴻博，2007，以回應曲面法探討添加陽離子界面活性劑透過溶膠-凝膠法製備矽膠之影響，中原大學化學工程研究所碩士論文第4-5頁。

24. 張正明，2002，酸性溶液下中孔徑分子篩的反應機構之探討，中原大學化學系碩士論文，第1-3頁。

26. 張正明，2002，酸性溶液下中孔徑分子篩的反應機構之探討，中原大學化學系碩士論文，第1-3頁。

2. M. Grätzel, 2001, “Ultrafast colour displays”, Nature, 409: 575.

3. S. H. Wang, T. C. Chou, and C. C. Liu, 2005, “Nano-crystalline tungsten oxide NO2 sensor”, Sensors and Actuators B, 94: 343-351.