The stock market always is the national economical display window, along with the relation between stock markets and macro economy is closely connected and inseparable. Decision makers and investors began to pay attention to the influence between economy and stock market. Therefore, this study examines the relations between the unemployment rate, which is one of the macroeconomic indicators, and domestic stock market. This study takes the unemployment rate as variables, and Taiwan Stock Index TAIEX as stock market indicator. In addition, this study utilizes the Asymmetric threshold Co-integration Model of Enders and Siklos (2001) to examine the co-integration relationship between unemployment rate and stock index. The error correction does not take place until the deviation crosses beyond a certain threshold, where the deviation reverts back to long-term equilibrium significantly at a high speed. According to the empirical results, this study suggests that investors should be more careful when unemployment rate is changing violently and adjust portfolios.