近紅外光譜非侵入式血糖檢測之研究

Non-invasive Blood Glucose Measurement Using Near Infrared Spectroscopy

姚肇鈞(Yau Jau Jiun)

指導教授 ： 張國清

義守大學/電機資訊學院/資訊工程學系/碩士(2014年)

https://doi.org/10.6343/ISU.2014.00325

摘要

本研究利用分時多工方法進行非侵入式測量手指微血管的血糖濃度。本研究使用1550nm，1570nm 和1590 nm 的波長，三個波長的光源，由三個低雜訊恆功率的雷射二極體驅動器驅動，經由四通道稀疏波分複用系統整合成一條光纖輸出至光纖準直透鏡，產生平行光束照射到樣本手指，經由手指反射的光通過光偵測放大器的檢測，再經過NI myDAQ 資料擷取器擷取光偵測放大器輸出的訊號，用於檢測血糖的濃度。
本研究利用偏最小二乘回歸和主成分回歸分析來建立校正模型，估算出血糖濃度。並進行口服葡萄糖耐試驗。結果顯示，所測得的光輸出具有與血液葡萄糖濃度有高相關性。

關鍵字

非侵入 ； 血糖 ； 近紅外光 ； 偏最小平方法

並列摘要

In this study, we develop a near infrared spectroscopy system by using time division multiplexing method for non-invasively measuring the concentration of blood glucose in the capillary of the fingers. The light sources are composed of three fiber coupled laser diodes with wavelengths of 1550 nm, 1570 nm, and 1590 nm, driven by three low noise constant power laser diode drivers. A four-channel coarse wavelength division multiplexing is used to multiplex these three wavelengths of laser light onto a single optical fiber. The output of the CWDM multiplex is connected to a fiber optical collimator for generating parallel light beams to illuminate the finger of the subject. The reflected optical output, detected by a high-sensitivity InGaAs amplified photodetector, was sampled by using a NI data acquisition module for estimating the concentration of blood glucose. The partial least squares regression and principle component regression were used to construct a calibration model and then estimate the blood glucose concentrations. The NIR system was applied to measure the change of blood glucose in the capillary of the fingers of young health subjects during an oral glucose tolerance test. Our results indicated that the measured optical output has high correlation with the concentration of blood glucose.

並列關鍵字

non-invasive ； blood glucose ； near-infrared spectroscopy

參考文獻

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