維他命 C 與低能量雷射 合併治療對於黑色素細胞瘤的影響

根據國民健康署公佈的 2015 年台灣癌症登記資料庫，皮膚癌在國人癌症發生率排行榜佔第八位，每 10 萬人就有 10 人罹患皮膚癌。目前治療皮膚癌主要的方式仍以手術切除為主。因此，我們期待找尋一個非侵入式的治療方式，來替代目前的切除手術。在多篇研究報告指出，高劑量維他命 C 具有抗癌性，但低能量雷射在癌症治療上的影響仍存有許多未知的地方。在本論文研究中，我們這選擇了維他命 C 及低能量雷射來對黑色素皮膚癌的治療進行評估，期望利用此兩種臨床上使用的藥物及技術能有加成的療效。研究結果顯示(1)高濃度維他命 C 合併低能量雷射 100 秒(1J)和 400 秒(4J)的組別能有效降低腫瘤細胞的存活率以及抑制增生。(2)經治療後，在蛋白質表現中，p-P38 蛋白的表現量降低。(3) 在動物實驗結果中，維他命C合併雷射400秒(4J/cm2)低能量雷射治療，其腫瘤生長率明顯較控制組低，維他命 C 合併雷射在抑制黑色素皮膚癌上有加成的效果。

關鍵字

黑色素皮膚癌；維他命 C ；低能量雷射

並列摘要

According to the data of the Top 10 cancer showed skin cancer is the eighth in the top ten cancer incidence rate of Taiwanese in 2015 by the Health Promotion Administration (HPA). Among the top five cancers with the fastest increase, it’s the second after the breast cancer. However, the main treatment of malignant melanoma is still use surgical resection now. Therefore, we are looking forward to find a non-invasive treatment for clinic. Previous studies have shown on high doses of vitamin C has the function of anti-tumor. And there are still many unknowns about the effects of low-energy lasers on cancer treatment. Therefore, we use these two treatments that have been used clinically to evaluate the effect on melanoma skin cancer growth. In this study, the data shown on (1) High concentration of vitamin C and low-energy laser can effectively reduce the survival rate and proliferation of tumor cells. (2) Decrease the phosphorylation of p-38 protein expression. (3) In animal experiments, the group with vitamin C combined with laser for 400 seconds (4J/cm2), the tumor growth rate was significantly lower than that of the control group. Our study shows that Vitamin C combines with low level-laser have a better effective for treat melanoma.

並列關鍵字

skin cancer ； malignant melanoma ； vitamin c ； low level last

參考文獻

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國際替代計量

維他命 C 與低能量雷射合併治療對於黑色素細胞瘤的影響

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