以甲基丙烯酸合成分子模板吸附咖啡因之研究

Study of the Adsorption of Caffeine on Methacrylate Synthesized Molecular Imprinted Polymer Beads

白孟巧(Meng-qiao Bai)

指導教授 ： 陳齊聖

朝陽科技大學/理工學院/應用化學系碩士在職專班/碩士(2011年)

摘要

分子模印技術是利用類似「抗原-抗體」作用的原理，透過複合物之聚合反應，形成一個與相同目標分子大小、形狀及化學功能性之互補位置以辨識目標分子的結構。
本研究以咖啡因 (Caffeine) 為模板分子、甲基丙烯酸 (MAA) 為功能性單體、乙二醇二甲基丙烯酸酯 (EGDMA) 為交聯劑，合成咖啡因分子模印高分子。探討在不同咖啡因濃度、溶劑極性、pH值等不同條件下，使用UV偵測模印高分子對於咖啡因之吸附效果。結果顯示，在溶劑效應當中，以10%的甲醇為最佳吸附溶劑，而且溶劑比例愈高，對於咖啡因吸附的效果愈差；在pH效應中，證明在酸性的條件下，較有利於模印高分子吸附咖啡因；最後，在溫度效應中，證明溫度的升高會減弱模印高分子對於模板分子的結合作用，使得咖啡因的吸附量降低。

關鍵字

甲基丙烯酸 ； 咖啡因 ； 分子模印高分子

並列摘要

Molecular imprinted technique (MIT) utilized interactions resembling the “antigen-antibody” binding. Through polymerization of the mixture of the target molecule and the monomer/crosslinking agent solution, complementary binding sites with the similar size, shape and chemical functionality to the target molecule may be formed on the polymer matrix.
This study used caffeine as the template and methacrylic acid (MAA) as the functional monomer, and ethyl glycol dimethacrylate (EGDMA) as the cross-linker, to synthesize the caffeine imprinted polymers. The major purpose was to investigate the adsorption pattern under various operation conditions, such as concentrations, solvent polarity, pH and temperature. UV-Visible spectrophotometer was used to detect and trace the variation of caffeine concentration in the solution. From which, the amount adsorbed can be obtained.
Experimental results indicated that about the solvent polarity, 10% methanol was the best adsorption solvent composition. Regarding the pH effect, adsorption data showed that acidic condition favored the caffeine adsorption. Temperature affected caffeine adsorption in a manner that upon temperature increase, the amount of caffeine adsorption was decreased.

並列關鍵字

Methacrylic acid ； Caffeine ； Molecular imprinted polymer

參考文獻

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