中文摘要 睡眠呼吸中止症是近十幾年來最常被醫界用來探討和研究睡眠不足或失眠原因的相關問題。睡眠呼吸中止症患者通常與肥胖有關,亦可能伴有粗短脖子的特徵。相較於身體質量指數(BMI)與體重,頸圍更可反應身體脂肪的累積。本研究根據文獻與臨床症狀,以病患的人口學特質資料為基礎,探討睡眠呼吸中止症的相關因素。 本研究以頸圍、BMI、頸圍/身高、體重等作為衡量身體肥胖的指標,以睡眠呼吸障礙指數、睡眠效能、高血壓、血氧濃度等作為衡量睡眠呼吸中止症特性的指標,探討這些身體肥胖指標與睡眠呼吸中止症特性的相關性。此外,本研究亦以打鼾、呼吸中止以及高血壓的發生與否調整(校正)頸圍,探討調整頸圍和睡眠呼吸障礙指數以及睡眠效能的相關性。本研究的樣本共有107位疑似睡眠呼吸中止症患者,以描述性統計、獨立樣本t檢定、多元迴歸分析等方法進行分析。研究結果發現,年齡較長以及患有高血壓患者的睡眠效能較差;BMI、頸圍、頸圍/身高以及校正後頸圍對睡眠呼吸障礙指數具有正相關;男性以及有抽菸的患者的睡眠呼吸障礙指數較為嚴重。此外,研究結果顯示睡眠呼吸障礙指數較高之患者的血氧濃度較低。 關鍵字:睡眠呼吸中止症、身體肥胖、身體質量指數、頸圍
Abstract In the last decade, sleep apnea syndrome has been widely investigated to study the issues of insomnolence in medical research. Generally, the patients suffering from sleep apnea syndrome share a common feature of “bullneck”. Neck circumstance (NC) can more effectively reflect the accumulation of body obesity when comparing to body mass index (BMI) and body weight (BW). In this research, we study the critical factors of sleep apnea syndrome based on the data of patients’ demographic characteristics. NC, BMI, NC/height, and body weight are used as the metrics of body obesity. Respiratory Disturbance Index (RDI), sleep efficiency, hypertension, and oxygen saturation are applied to represent the characteristics of sleep apnea syndrome. In this research, the relationship of body and the sleep apnea syndrome are investigated. The relationship of demographic characteristics other than body obesity to sleep apnea syndrome is also studied. Moreover, the relationship between the adjusted NC and RDI (or sleep efficiency) is investigated. The research sample includes 107 subjects which are potentially suffering from the sleep apnea syndrome. The descriptive statistics, t test, analysis of variance, and regression analysis are used to analyze the sample data. It is shown from the results of this study that the patients with older age and hypertension have significantly worse sleep efficiency. The higher values of BMI, NC, NC/height, adjusted NC result in significantly higher value of RDI. In addition, higher value of RDI will be accompanied with lower average value of oxygen saturation (or minimum oxygen saturation). Keywords: sleep apnea syndrome, body obesity, BMI, neck circumstance.