低溫電漿改質ePTFE膜及表面固定鈦/磷氧化物之研究

The Study of Plasma Modified ePTFE Films and Surface Immobilization of Oxides of Titanium and Phosphorus.

葉怡君(Yi-chun Yeh)

指導教授 ： 陳克紹

大同大學/工程學院/材料工程學系所/碩士(2006年)

摘要

拉伸性鐵氟龍(expanded polytetrafluoroethylene，ePTFE)薄膜為一表面極為疏水的安定性多孔性材料，為改善並提升其表面親水性及賦予表面抗菌及吸附菌體特性，本研究利用(1)低溫電漿處理於ePTFE 膜表面進行親水性改質，(2)以溶液凝膠法旋轉塗怖有機鈦薄膜，(3)氧氣電漿處理取代傳統燒結處理，將表面的有機鈦氧化有機物，最後(4)將氧化鈦薄膜浸泡 5wt%磷酸鈉溶液以低瓦數的UV光照射活化表面及吸附固定磷酸根結合使表面磷酸化。首先利用低溫HMDSZ電漿(10W/10min/50mtorr)沉積有機矽膜於ePTFE表面，以氧氣電漿(50W/10min/200mtorr)活化有機矽膜，由親水性變化結果顯示，經由雙重電漿處理後基材表面親水性提高(125°→8°)。表面塗佈有機鈦薄膜，以氧氣電漿處理(75W/45min/200mtorr)氧化形成氧化鈦膜，由化學分析表面鍵結結果顯示，基材表面有Ti-C、Ti-O、TiO2鍵結出現。以UV光活化氧化鈦薄膜固定磷酸根，以元素分析及化學鍵結分析結果顯示，基材表面有P原子產生、O-P-O鍵結出現，藉此佐證成功使表面磷酸化。抗菌測試表面抗菌及吸附菌能力，發現表面磷酸化的基才在無光線的情形下與對照組比較，表面磷酸化具有吸附菌體能力，UV光照射下，可在20~30分鐘達到表面抗菌效果。

關鍵字

電漿 ； 表面固定 ； 抗菌

並列摘要

Expanded polytetrafluororthylene (ePTFE) film is a kind of surface hydrophobic materials. The titania coating can improve the surface antibacterial and absorptive bacterium properties. The commercial method for titania coating is spin coatings. Since the hydrophobic surface of ePTFE film makes the spin coating infeasible, the plasma polymerization of HMDSZ and subsequent plasma oxygen treatment is required to enhance hydrophilic properties. It was found that hydrophilic groups, e.g. hydroxyl and silicone-oxide species, can be formed on the surface-modified by plasma treatment. The water contact angle was substantially decreased from 125° to 8°. In term of water contact angle , the optimal treatment is HMDSZ plasma(10W/10min/50mtorr) and Oxygen plasma (50W/10min/200mtorr). On the plasma-treated surface, the TiOx-containing film was spin-coated (1200 rpm, 25s) from sol-gel solution. Conventionally the as-spinned film was annealed to reduce the organic residues. However, the high temperature treatment is not appropriate for the thermal-sensitive organic materials, such as ePTFE. In this study, the post plasma oxidation was attempted to reduce the organic residues of the TiOx-containing film on ePTFE. In term of water contact angle, the optimal treatment is Oxygen plasma (75W/45min/200mtorr). After plasma oxygen oxidation, the relative intensity of methyl group to the Ti-C, Ti-O and TiO2 groups was found to increase from the chemical analyses. After immobilization, the presence of P atom and O-P-O on surface indicates the phosphate ion is successfully immobilized by UV irradiation. The antibacterium test shows that the amount of bacteria was decreased after TiOx coating with oxygen plasma treated. To enhance the antibiotic behavior, the surface phorylation can facilitate the absorption of bacteria to “trap” the bacteria in dark. The synergetic effect of trapping of bacteria on phorylated sites and the intrinsic antibiotic properties of titania can further enhance the antibiotic effect on the ePTFE. The surface phorylation would gradually reduce the population of bacteria after 20min ~30 min UV irradiation in antibiotic test. The reproductivity of the antibacterium properties seems to be fairly good in this method.

並列關鍵字

antibiotic ； plasma ； surface immobilization

參考文獻

4.Xiao-Lin Wanga*, Jian Huangb, Xiu-Zhen Chen”, Xue-Hai ,Desalination 146 (2002) 337-343

5. Meiping Wu, J. Appl. Polym. Sci. Vol 43, pp2067-2082(1991).

1. T. R. Dargavillea, G. A. Georgeb, D. J. T. Hilla, and A. K. Whittakerc, Prog. Polym. Sci. 28, 1355–1376(2003).

2.Sujata V. Bhat, Biomaterials, Alpha Science International Ltd, Pangbourne England, 2002.

3.U. Konig, M. Nitschke, A. Menning, G. Eberth, M. Pilz, C. Arnhold, F. Simon, G. Adam, and C. Werner *, Colloids and Surf. B: Biointerf. 24, pp 63–71(2002).