丙烯酸與丙烯醯胺UV光共聚合成感溫性水膠之研究

Preparation of Temperature-Sensitive Hydrogels by UV-induced Polymerization of AAc-co-AAm

陳瀅如(Ying-Ju Chen)

指導教授 ： 陳克紹

大同大學/工程學院/材料工程學系所/碩士(2010年)

摘要

智慧型水膠可藉由外界的刺激而造成膠體的膨脹、收縮或彎曲，如：外在環境的溫度、pH、電場、磁場、光、生物活性分子或離子強度的改變。因此可利用其特性於藥物釋放系統或做為人工肌肉、人工器官、生物感測器……等。目前最為廣泛研究的智慧型水膠是溫度敏感性水膠，利用LCST (lower critical solution temperature)性質，來改變水膠的物理和化學性質。本研究是利用UV光來照射丙烯醯胺(AAm)及丙烯酸(AAc)的混合單體溶液，聚合成感溫性水膠。此感溫性水膠在6℃左右會產生結構上的變化，使水膠顏色由透明轉變為乳白色，此現象被定義為UCST (upper critical solution temperature)。
本實驗方式是利用UV光的高能量使AAc及AAm單體快速的聚合，實驗結果得知當AAm與AAc在一定比例下，聚合成的水膠在UCST溫度以下之環境，會有化學結構上的改變，探討不同單體濃度對不同酸鹼值下其膨潤效果變化，並利用微差掃描熱分析儀(DSC)以測試其相轉變溫度，相轉變溫度大約在6℃。利用傅立葉轉換紅外線光譜儀(FTIR)與電子顯微鏡(SEM)觀察其結構與型態變化，利用萬能測試儀(Universal Tester)測試其機械強度，以及不同溫度下水膠之水接觸角變化。

關鍵字

丙烯酸 ； UV光聚合 ； 感溫性水膠 ； 丙烯醯胺

並列摘要

External environment can induce the smart hydrogels to have inflation, shrinkage and bending. For example, the temperature, pH, electric field, magnetic field, light, bio-activity, and the change of ionic strength. Hence, it could be used in drug delivery system for artificial muscle, artificial organ, bio-sensor…etc. Now widely investigate smart hydrogel is temperature sensitive hydrogel, using LCST (lower critical solution temperature) to shift chemical and physic properties of hydrogels. In this study , using high power UV-light to irradiate AAm and AAc mixing solution, to form temperature sensitive hydrogels. This kind of hydrogels would change there structure at UCST (upper critical solution temperature), the color would be change at the same time immediately.
This study discuss the effect that degree of polymerization by ratio of AAm to AAc concentration. Assay the characteristic of swelling and the effect of temperature…etc. The FT-IR shows that the peak of functional groups –COOH and -CONH2 of AAc and AAm, ,respectively ; then the DSC shows that the Tg is 6℃；the swelling is about one hundred ratio；then SEM micrographs to observation structure of hydrogels.

並列關鍵字

Acrylic Acid ； UV-induced Polymerization ； Temperature-Sensitive Hydrogels ； Acrylamide

參考文獻

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