In this thesis, the design of integral sliding mode controller for continuous-time multiple-input multiple-output (MIMO) linear time-invariant (LTI) polytopic dynamic system with state and input delays is investigated. First, the state transformation is applied to eliminate the effect of input delay. Next, we design an integral sliding mode controller to solve the control problem. Based on the Lyapunov stability theorem, we can derive linear matrix inequality (LMI) criterion for the stability of a time-delay system. Finally, a numerical simulation example is given to demonstrate the effectiveness of the proposed control strategy.