健康檢查GOT、GPT、AFP肝指數篩檢與酒精性肝炎相關性的探討

Investigation of the Relationship between GOT, GPT and AFP in Physical Examination and Alcoholic Hepatitis

詹佩蓉(Pei-Jung Chan)

指導教授 ： 許垤棋

大同大學/工程學院/生物工程學系所/碩士(2010年)

摘要

本研究嘗試對於健康檢查的群體做統計學上的分析，利用一般常規健檢所測得肝指數，配合一般體檢單上健康諮詢欄位中生活習慣等做為選項，代入統計系統做運算。本論文提出經由三組( GOT、GPT、AFP)肝指數作為酒精性肝炎高危險率評估系統。這是藉由表單上填寫生活習慣(飲酒、運動、B型肝炎表面抗原)劃分八組別，在這三組指數上所顯現出的差異度，以其所得的統計數據來做事後分析，並進行組別間的比較，以觀察到底哪一組所受危險因素影響最大。
在實驗上，我們將組別分為八大組，分別是飲酒(+/-)、運動(+/-)、以及HBsAg(+/-)來做為排列組合，並將不同組別間分別去做分析比較，來分析GOT、GPT、AFP在這些組別間數據上有何明顯有意義的顯著性差異，以及影響明顯顯著性其成因為何。我們利用統計套裝軟體系統SPSS(Statistics Package for Social Science)來做分析，首先以Levene’s test作為變異數同質性檢定，以判斷其差異性，再以one way ANOVA作為統計學上的檢定方式，以觀察差異顯著性，最後再以Tukey’s法作為結果後分析，以進行成對比較，來觀測所得數據結果是否具有統計學上的意義。結果上發現，GOT於飲酒組中增幅具有較為明顯的變化，其次為GPT，AFP則不具有顯著性。因此可知經由健康檢查對於篩檢酒精性肝炎仍有其價值性。

關鍵字

統計套裝軟體系統 ； 酒精性肝炎

並列摘要

This work is trying to statistically analyze the group of people being under a regular physical examination to obtain the liver index along with the check box of life habits shown on the health column in the examination form. This study bring up 3 groups of index(GOT,GPT and AFP) as the evaluation system to evaluate the high risk rate of Alcoholic Hepatitis by dividing the life habits(wine drinking, exercising, and HBsAg) obtained from the survey form into 8 groups, where the 3 groups of liver index apparently show discrepancy whose statistic data can be used to proceed with the post analysis and group comparison to observe which group is mostly affected. Experimentally, the groups are divided into 8, including wine drinking(+/-), exercising(+/-), and HBsAg(+/-), to do observe what meaningful significances of GOT, GPT and AFP shows and what causes these significances. First of all, Levene’s test in SPSS is used to do the test of Homogeneity for variables to determine the differentiation, following with one way ANOVA as statistical examination to observe significant discrepancy, and at last, Tukey’s test is used for post-result analysis on the pair comparison to determine if the final outcome is statistically meaningful. The result shows that the increase of GOP index is significant in the wine drinking group, followed by GPT index, but on for AFP index, which is not significantly changed. Therefore, it’s concluded that physical examination is valuable for screening the high risk group of Alcoholic Hepatitis.

並列關鍵字

SPSS(Statistics Package for Social Science) ； Alcoholic Hepatitis

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