- 學位論文
UV 光接枝聚合異丙基丙烯醯胺於經冷電漿表面處理聚苯 乙烯表面
UV-Induced Grafting Polymerization of N-Isopropylacryamide onto Polystyrene Surface by Cold Plasma Deposition(CPD)
摘要
聚苯乙烯(PS)為日常生活中，常見之高分子材料，基材表面光滑、疏水性質、低表面能及表面生物惰性，使得基材表面的吸附性質及生物相容性不佳。本研究將基材表面先行以六甲基二矽胺烷(HMDSZ)及氧氣(O2)電漿，進行表面電漿沉積/活化處理，於表面沉積一層有機矽胺烷類或極性官能基，再利用氧氣電漿活化表面處理，在表面產生含氧的極性官能基，及使表面親水化，以便在紫外光接枝聚合異丙基丙烯醯胺(NIPAAm)時，提升接枝率。最後以交聯劑交聯化學方式，將生物性高分子固定在水膠上方。在電漿的過程中，以石英振盪晶體(QCM)輔助量測鍍膜重量並計算出沉積速率。聚異丙基丙烯醯胺(PNIPAAm)是一種具有特殊相變化的智慧型感水溫膠，在低於低溫臨界溫度(LCST)，產生親水及體積膨脹，相反低於LCST時會有相反之特性。經UV-vis及DSC量測結果PNIPAAm之低溫臨界溫度約為33.5℃，且在不同溫度(25℃及40℃)下量測水接觸角亦有明顯改變。且經由FT-IR及Raman分析，可以知道聚苯乙烯表面經UV光接枝後，在表面產生異丙基丙烯醯胺之特殊官能基如N-H基、C=O基及C-H。從ESCA結果可以得知，在表面C、N及O元素比例明顯變化。
並列摘要
Polystyrene (PS) is one of important and has usually been used. However,there are troublesome problems for PS because it`s hydrophobicity, low surface energy and surface inert-bio, that induces poor adhesion and coating properties. Chemical Vapor Deposition (PECVD) using Hexamethyldisilazane(HMDSZ) and oxygen(O2) is performed to plasma deposit and activate the substrate surface, and produce alkyl-amino, alkyl-oxygen or functional group on substrate surface. After plasma surface treatment, photo-induced grafting polymerization of N-isopropylacrylamide (NIPAAm), and cross linking of biomaterial like chitosan on PNIPAAm surface. Quartz Crystal Microbalance (QCM) were used to measure the weight change of substrate for different plasma treatment. Poly(N-isopropylacrylamide) (PNIPAAm) has been extensively investigated for temperature-modulated drug delivery systems due to its thermosensitive properties, such as the lower critical solution temperature (LCST of 32 ℃), above the LSCT, Below LCST, the hydrophilic PNIPAAm chains interact with water. From FTIR, Raman analysis, there are some special function group like amine group、C=O and C-H function group on PS surface after UV light grafted PNIPAAm. From ESCA analysis, the ratio of C、N and O elements were changed before and after PD-HMDSZ and grafted PNIPAAm.