表面含矽氧結構之熱敏性混成凝膠的製備與性質研究

STUDIES ON PREPARATION AND PROPERTIES OF THERMOSENSITIVE HYBRID HYDROGELS CONTAINING SILOXANE STRUCTURE IN SURFACE

陳芝寧(Chih-ning Chen)

指導教授 ： 李文福

大同大學/工程學院/化學工程學系所/碩士(2011年)

摘要

本研究係以N-isopropylacrylamide (NIPAAm) 和N-vinyl-2- pyrrolidone (N-VP) 為主，先製備熱可逆凝膠材料，再吸附tetraethoxysilane (TEOS) 後，進行Sol-Gel反應，製備有機無機混成膠體。本文主要探討不同交聯劑含量對混成凝膠材料之膨潤度、膨潤動力、機械性質、孔隙度、膠體形態、靜態水接觸角及對bovine serum albumin (BSA) 吸附性影響。結果顯示膨潤度、機械性質、孔隙度、膠體形態、靜態接觸角及BSA蛋白質吸附量主要受到交聯劑比例成份不同，以及無機成分導入所影響。首先以自由基聚合法製備三種不同比例交聯劑之膠體，當交聯劑含量越高，膠體結構越緊密，具有較佳的機械性質與靜態接觸角度，但較低的膨潤度、孔隙度、BSA蛋白吸附量，以及溫度敏感性降低。
接著導入第三成份疏水性之TEOS，以溶膠凝膠方式反應而成之膠體，探討其對膨潤行為、機械性質、孔隙度、BSA蛋白質吸附量以及膠體形態的影響。結果顯示膠體性質會受到導入TEOS之矽氧烷成份所形成之互穿網絡結構 (IPN) 所影響，導致溫度敏感性、孔隙度、膨潤度值下降。另外，由掃描式電子顯微鏡 (SEM) 圖發現膠體之小孔洞被矽氧成份所填滿而導致膠體結構更為緊密，因此其機械強度與交聯密度值增加。接著由SEM圖與顯微鏡觀察膠體表面，發現成功導入TEOS之矽氧烷成份後，膠體表面形成小圓顆粒並有龜裂現象產生，遂使靜態接觸角度值下降。此外，由於膠體之疏水性增加，及其結構更加緊密，而使BSA蛋白質吸附量明顯下降。由此可以推論導入TEOS之矽氧烷成份後，可明顯改善膠體沾附BSA的結果。

關鍵字

有機無機混成水膠 ； 溫度感應性 ； 四乙氧基矽烷 ； N-異丙基丙烯醯胺

並列摘要

A series of thermosensitive hydrogels based on N-isopropylacrylamide (NIPAAm) and N-vinyl-2-pyrrolidone (N-VP) with various crosslinker contents were prepared by free radical polymerization at first, then the hydrogels absorbed tetraethoxysilane (TEOS) to prepare a series of thermosensitive hybrid hydrogels through sol-gel reaction. The effects of various crosslinker contents on the swelling ratio, mechanical properties, static contact angle, pore sizes and absorption of bovine serum albumin (BSA) of the copolymeric hydrogels was investigated in this study. The results showed that the swelling ratio, mechanical properties, pore sizes, static contact angle, morphology, drug release, and BSA concentration determination would be mainly affected by various situations of the copolymeric hydrogels structure caused by introduction of inorganic moiety and various crosslinker contents. As the content of crosslinker increased, the hybrid gels showed stronger moduli, higher static contact angles and crosslinking densities. The swelling ratio, pore sizes, drug release, BSA concentration, and thermosensitivity of the copolymeric hydrogel (NIPAAm/N-VP) decreased with an increase of crosslinker. As introducing TEOS into PNIPAAm/N-VP series hydrogels, the results showed a stronger modulus, lower static contact angle, and higher crosslinking density. The swelling ratio, pore size, drug release, and thermosensitivity of the hybrid gels decreased with introduction of TEOS content. Total BSA concentration absorbed on the copolymeric hydrogel decreased with increasing hydrophobic surface and denser gel structure. The evidence showed that introduction the siloxane structure into the surface of the hydrogel via sol-gel reaction of TEOS can diminish the adhesion of protein on the hydrogel.

並列關鍵字

organic-inorganic hybrid ； thermosensitive ； TEOS ； NIPAAm

參考文獻

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