- 學位論文
利用實驗設計法於凝膠劑量計成分之最佳化研究
A systematic approach to determine optimal composition of gel used in radiation therapy
摘要
惡性腫瘤持續成為我國十大死因之首，放射治療的方式越來越顯的重要。作為放射治療評估工具的聚合物凝膠劑量計（gel dosimeters）擁有立體劑量分佈的特性，可為偵測3D立體劑量分佈之工具，能評估治療計畫。 本研究以雷射掃描系統量測NIPAM聚合物凝膠，以實驗設計法對NIPAM凝膠進行實驗設計與分析，尋找NIPAM凝膠在成分比例上，較佳配方，增加NIPAM凝膠本身的穩定度及敏感度並瞭解其特性。 聚合物凝膠配方需因劑量區間的不同而有所變動。而聚合物凝膠受到輻射照射後所產生的聚合作用，會因氧氣而造成抑止作用，故製作上必須於無氧環境下或加入抗氧劑。於低劑量照射下，若凝膠內殘留氧氣，則會造成抑止聚合作用，而使劑量反應誤差大，故接受劑量低時，抗氧劑（THPC）含量需增加。 若有良好的保存，則可以維持凝膠的穩定性及常效性。凝膠製成後需存放於低溫下，避免高溫造成其他化學反應。也應盡量維持於無光環境，避免凝膠於光線中微量輻射進行聚合反應，而使的量測上，造成劑量反應誤差大。
並列摘要
Malignant neoplasms (cancer) is the top one of 10 leading causes of death for people in Taiwan. radiotherapy treatment is important for cancer. Polymer gel dosimeters with the characteristics of three-dimensional dose distribution is extremely suitable in radiation therapy dose verification. It`s used to measure plan. In this study, laser optical computed tomography (OCT) was used in dose distribution of the NIPAM polymer gel. The design of experiment (DOE) was used to find the optimal composition of NIPAM gel. The availability of the best formula to increase the stability and sensitivity of NIPAM Gel, and understanding of their properties. Different dosage interval have to change of polymer gel formulations. The polymer gel after irradiation by the radiation produced by polymerization, a result of curbed because of the role of oxygen, it must be produced in anaerobic conditions or by adding antioxidants. Residues of oxygen in the gel will result in an inhibition in the low-dose region, the large deviations encountered in dose-response. Therefore, when receiving the low dose, need to an increase antioxidant (THPC) . In a good save an maintain the stability and regular gel effectiveness. After fabrication had to stored in low temperature to avoid high temperature caused by other chemical reactions. Also should be avoid micro-gel in the light of radiation polymerization. Avoid causing large deviations encountered in dose-response by measurements.