評量病人在接受核子醫學檢查時的體內動力學 及水假體驗證

本研究是利用多腔室水假體及MATLAB程式來模擬多個生物動力學模組以估計體內劑量,藉以推論於核醫檢查時,預測體內組織器官中放射性藥物的代謝。在實驗過程中,透過兩種假體,來假定生物體內動力學模組,再分別透過微分方程來將其定義,以獲得水假體內的放射性藥物濃度與時間的變化。透過MATLAB程式與γ-camera掃描來分析動態水假體腔室內放射性藥物的濃度與時間的變化。而符合度AT驗證則是用於評估各情況下的比較。本實驗使用兩種水假體,其中一個為訂製封閉式水假體做為前導實驗,另一個則由七個不同尺寸的丙烯酸盒組裝而成,盒子間以不同的軟管組合相連,從生物醫學的角度來表示多種生物動力學模組。將129.0±24.2MBq的Tc-99m標記的亞甲基二膦酸鹽(MDP)溶液完全注入水假體中,然後用去離子水替換假體內的水以模擬各腔室之間的生物去除率。並利用自動注射器以6.7c.c./min的速度將水注入替換。四個不同大小的盒子的生物半衰期分別為4.8, 10.7, 18.8和45.5分鐘。本實驗成功模擬了人體內的生物動力學變化,推導出的生物動力學模組可以代表人體內的代謝機制,並通過定量分析的驗證。再進行人體試驗,來驗證真實體內動力學。本人試驗分成兩部分,分別為腸胃道模組與甲狀腺模組。在腸胃道模組內,評估25位健康志願者,其中女性14人,其中一人採個案討論,餘13人平均年齡為36.23歲;男性11人,平均年齡34.18歲。男女對象依照年齡及身體質量指數(BMI)各分兩組來評估Tc-99m phytate於體內之胃排空時間及量化小腸吸收之生物半衰期(λb)。所有受試者於實驗前皆禁食不禁水至少六小時,並於檢查前食入兩片烤土司中夾混有放射性藥物0.5mCi Tc-99m phytate之烤蛋,以及一杯150c.c之5%葡萄糖水溶液。並利用γ-camera每半小時動態掃描,每張掃描五分鐘,圈取感興趣區(ROI)後,記錄各部位隨著時間變化之計數值,並利用Excel及MATLAB程式來分析;而甲狀腺模組內,則有五位患者參與本次研究,其中4位女性1位為男性(年齡範圍為37歲至46歲),其都接受過甲狀腺全切除術後,連續四週每位病人給予1.11G Bq (30mCi)之I-131膠囊服用,以清除殘餘之甲狀腺腫瘤及組織,再進行連續四週的γ-camera掃描。藉由體內測量分析後,再來比較其MATLAB理論值與實際測量之實際值之AT符合度分析一致性與誤差探討。關鍵字:核子醫學、體內劑量、多腔室水假體、體內動力學模組、MATLAB程式

關鍵字

核子醫學；體內劑量；多腔室水假體；體內動力學模組； MATLAB程式

並列摘要

The aims of study were to integrate and evaluate multiple biokinetic models using MATLAB program. Nevertheless, the topic in this study also focused on to estimate internal dosage and to predict the time-dependent quantity of radiolabeled complexes in crucial organs. In the phantom study stage, two kinds of phantom were applied. One was a customized PMMA phantom with closed water flow loop that was tested and verified as preliminary survey, whereas another one was assembled by various sizes of PMMA boxes and connected each other by silicon hoses that were assigned as the major tested task in this study. Accordingly, five biokinetic models were separately defined by five groups of simultaneous differential equations to obtain the time-dependent radioactive concentration changes separately to the different two water phantoms. The five groups of derived time-dependent concentrations for the boxes were estimated either by a MATLAB program or by scanning via a gamma camera facility. The water phantom was assembled from seven different sized acrylic boxes that were connected to different hose combinations to represent multiple biokinetic models from a biomedical perspective. The boxes that were connected by hoses were then regarded as a closed water loop with only one infusion and drain. 129.1±24.2 MBq of Tc-99m labeled methylene diphosphonate (MDP) solution was fully infused into the water boxes before gamma scanning, then the water was replaced with de-ionized water to simulate the biological removal rate among the boxes. The water was driven by an automatic infusion pump at 6.7 c.c./min. and the biological half-life of the four different sized boxes was 4.8, 10.7, 18.8, and 45.5 min. The derived biokinetic model represented the metabolic mechanism in the human body and helped to solidify the internal circulatory system into reality with numerical verification. The in-vivo survey of both the gastro-intestinal tract (GI Tract) and the iodine thyroid biokinetic models were performed to verify its practical application. A dimensionless agreement (AT) index was recommended to evaluate the comparison in each case. A minimal AT was always preferable for implying a high consistence between empirical and theoretical outcome. The derived ATs were all below 50 indicating a convincible and reliable result in this study. Keywords: nuclear medicine, internal dosage, biokinetic model, multi-compartments water phantom, MATLAB program

並列關鍵字

nuclear medicine ； internal dosage ； biokinetic model ； multi- compartments water phantom ； MATLAB program

參考文獻

[1] Kuang Hua Chu, et al. Evaluation of effective dose for a patient under Ga-67 nuclear examination using TLD, water phantom and a simplified model, Journal of Radiation Research, 2012, p1–10

Google Scholar

[2]RW Leggett: Biokinetic models for radiocaesium and its progeny, Journal of Radiological protection, 2013;33: p123–140

Google Scholar

[3]Brudecki Kamil et el. Comparison of whole body retention of I-131 in case humans thyroid cancer between model prediction and measurement, Nuclear Medicine and Biomedical Imaging.,2016: Volume 2(1): 1-5

Google Scholar

[4]Pei-Jung Li et al. Evaluating the four compartment biokinetic models with MATLAB – A feasibility study of dynamic water phantom (Master thesis),中臺科技大學放射科學研究所,2014

Google Scholar

[5]Jing-Fa Tang et al. Quantitative evaluation of seven compartments bio-kinetic model in dynamic water phantom using MATLAB program: a feasibility study (Master thesis),中臺科技大學放射科學研究所,2015

Google Scholar

國際替代計量

評量病人在接受核子醫學檢查時的體內動力學及水假體驗證

全文下載

主題瀏覽