The main purpose of the research is to analysis how smoking cessation endorsement and different styles of smoking cessation advertisements effects the willingness of smoking cessation to smokers. The experimental designed method of the research is divided into control group and experimental group (celebrity endorsement, expert endorsement, representative consumer endorsement, heartwarming smoking cessation advertisement, humorous smoking cessation advertisement, terrifying smoking cessation advertisement). “Questionnaire of which type of smoking cessation endorsement and advertisement can enhance the willingness of smoking cessation to smokers” was taken as the research tool. Taking the convenience sampling method, there is 420 valid questionnaires in total. Using the One-way Analysis of Variance (One-way ANOVA), we found out that three types of the endorsement that are chosen by this research have significant effects on smokers’ decision. While heart-warming advertisement and terrifying advertisement also have significant effects on smokers’ decision. Humorous advertisement has less effects on the smokers’ decision of quitting smoking. This result can be a reference for advocacy of relevant units that promote smoking cessation.