五十二種中藥萃取物抑制酪胺酸酵素與清除自由基能力之研究

Effect of Water and Ethanol Extracts from 52 Chinese Herbal Medicines on Inhibition of Tyrosinase Activity and Free-radical generation

王惠儀(wang kui fang)

指導教授 ： 李明明

亞洲大學/人文社會學院/生活應用科學學系碩士班/碩士(2007年)

摘要

糖尿病是由於患者體內的胰島素分泌不足或作用不良，對醣類的利用能力減低甚至於完全無法利用，而造成血糖過高，尿中有糖的現象，同時也造成蛋白質和脂肪的代謝不正常。
營養治療(Medical nutrition therapy) 是糖尿病整體照顧與管理不可缺少的一部份。雖然依照營養和飲食計劃去做，是最具挑戰的事，但不可諱言的，營養治療卻是成功控制糖尿病的必需要素‧糖尿病在中醫學中被稱為消渴症或三多症（即多食、多飲及多尿）。消渴症患者經常感到口乾、口渴，即使不斷喝水也無濟於事。這種缺水現象,則是由於身體陰分不足所導致，「陰」則泛指身體內的體液及津液。飲食不當則是造成腎陰不足的最主要原因。進食過多的高脂肪、高熱量及醣類食品，容易導致熱毒積聚，傷及臟腑，內熱若持久不散則會令津液乾涸。在身體燥熱之餘，往往因煩勞過度而虛弱，最終會影響內分泌系統，導致新陳代謝紊亂。胰島素功能因而失常或分泌不足，令血糖過高使糖分流入尿液，因而產生糖尿的現象‧
本研究結合中醫消渴症食療與西方營養科學。為此，在本論文中，我們以知識庫的架構，建置一專為消渴症中醫營養食療專家管理系統,提供一個專屬消渴症病人之整合式查詢介面，以整合西方醫學與中醫相關食療資料庫。藉由經過清楚且明確的分類架構體系，以及整合式單一介面的查詢輸入，可以提供消渴症病人快速搜尋而取得有用的食譜，使其在參考與研究上有顯著且大量的幫助。

關鍵字

糖尿病 ； 消渴症 ； 知識庫、營養素、整合式查詢

並列摘要

Diabetes is caused by the inadequate secretion or malfunctioning of insulin in the patient’s body, which reduces the utilization of carbohydrate even to the extent of complete inability to use it, which then causes high reading of blood sugar as well as sugar in the urine, at the same time causing the metabolism of protein and fat to be abnormal. Medical nutrition therapy is an essential part of the diabetes care and administration program. Although it is most challenging to follow the Diabetes Mellitus diet, it is without doubt that Medical nutrition therapy is indispensable in successfully controlling diabetes.
In traditional Chinese medicine, diabetes was called ‘the disease of acute thirst’ or ‘the three excessive disease’ (i.e. excessive eating, excessive drinking, and excessive urinating). Patients of the acute thirst disease often feel dry and thirsty, which cannot be helped by continuous drinking. This phenomenon is caused by the inadequate 'yin' (or negative) element in our body, which refers to the deficiency in fluid and blood in the body. Inappropriate diet is the main cause for the inadequacy of 'yin'. Eating too much fat, calorie and carbohydrate often causes the accumulation of poisonous heat, damages the internal organs, and if the heat congregates do not disperse over a long time, the fluid and saliva will be drained. When the body is hot and restless, it becomes weak by excessive stress and loading. Ultimately, this will affect the endocrine system and confuse metabolism processes of human body. The function of insulin becomes abnormal or inadequate, blood sugar becomes excessive and flow into the urine, causing thephenomenon of elevated blood sugar.
It’s importantly, this study for Diabetes Mellitus both combines the traditional Chinese medical treatment and the Western nutritional theory. In this study, we construct a query interface based on several knowledge banks in the form of a Medical nutrition therapy of expert management system which incorporates databases from both Chinese and Western medical practice and especially designed for the patients of the acute thirst disease. Through the clearly defined and hierarchically categorized system, and an integrated unique query interface, the patient can quickly obtain useful diets provided by the system. In conclusion, the query system offers a great of advantages in Diabetes study or practical healthcare.

並列關鍵字

diabetes ； acute thirst disease ； knowledge bank, nutrition ingredient

參考文獻

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