化學治療後口腔潰瘍及感染於惡性淋巴瘤預後之影響－小球性淋巴瘤併有單株副蛋白血症之病例報告

Prognostic Influence of Chemotherapy Induced Mucositis on a Lymphomatous Patient with Monoclonal Paraproteinemia

李艷珠(Yen-Chu Lee) ； 吳宗忠(Tzong-Jong Wu)

《中華民國口腔顎面外科學會雜誌》 5卷2期 (1994/09) Pp. 23-28

https://doi.org/10.7104/CJOMS.199409.0023

摘要

79歲男性病人，罹患小球性林巴瘤併單林副蛋白血症(monoclonai paraproteinemia)，屬罕見病例。經每日一次oncovin, cyclophosphamide, prednisolone等9次化學治療，病情穩定。然於出現化療後口腔潰瘍時，由於口腔疼痛而拒絕進食，營養狀況變差，抵抗力減弱。且口腔引起綠膿菌感染併發全身敗血症終至死亡。口腔潰瘍常發生於化療後白血球際低時期，易併發口腔感染或敗血症，對於病程治療預後會造成影響。

關鍵字

惡性淋巴瘤 ； 單株副蛋白血癥 ； 口腔潰瘍 ； 化學治療

並列摘要

A 79-Year-male patient came to our hospital with initial chief problem of anemia, was diagnosed as a case of small lymphocytic lymphoma with monoclonal partaproteinemia. Globulin level lowered after chemotherapy with Cop regimen (cyclophosphamide 600 mg /m^2 IV, oncovin 1.4 mg/m^2 IV, prednisolone 1 mg/kg/d oral for 5 day), But tumor mass did not subsided completely. At his last admission on November 2, 1993, doxorubicin (30 mg/m^2) was added for treatement, mucositis and oral ulcer developed at bilateral buccal mucosa and sublingual area despite azohel solution gurgling. Cachexia developed due to oral pain and poor intake. Septicemia occurred on November 23 and the patient died on the next day. Mucositis with oral ulcer in cancer patient receiving chemotherapy seemed play some roles in prognostic influence.

並列關鍵字

malignant lymphoma ； monoclonal paraproteinemia ； oral ulcer ； chemotherapy