Chylous leakage is a potentially mobility that results from lymphatic duct injuries in radical neck dissection. This may cause nutrition impairment, delay wound healing, and prolong hospitalization. Patient often become nervous when they note large volume milky-like component drained from the operative wound. There are several modalities to treat chylous leakage, including ligature and application of glue to the leakage region, injection chelating agent (tetracycline) and low- fat diet adjustment. We report one chylous leakage case in our oral and maxillofacial department by using low-fat diet through total parenteral nutrition (TPN) administration to treat the chylous leakage.