過敏性鼻炎緩解期中醫治療研究

Study of Chinese Medical Treatment of Remission of Allergic rhinitis

楊賢鴻(Hsien-Hung Yang)

《中醫藥研究論叢》 10卷1期 (2007/03) Pp. 159-173

https://doi.org/10.6516/TJTCM.200703_10(1).0015

摘要

本研究在針對經年型的「過敏性鼻炎」患者，在急性期經治療後，進入緩解期給予中藥複方「補中益氣湯」服用，以了解服用中藥對人體免疫機轉調節之影響。
研究中將病患隨機分爲兩組，實驗組給予中藥「補中益氣湯」，對照組給予「平胃散」，兩組分別治療二個月後進行評估，實驗組患者的臨床症狀指數評估結果顯示，治療前的3.21±0.08到治療後的0.56±0.09有統計上的差異，進一步探討作用機轉，我們發現實驗組的血清中IgE值及以IL-4刺激嗜中性白血球的上清液中，PGE2及LTC4產生的濃度，在治療前後相比較明顯受到抑制，然而此情況並不見於對照組。實驗結果發現中藥「補中益氣湯」治療緩解期過敏性鼻炎、可顯著改善臨床症狀、此臨床症狀的改善，可能與體內組織局部發炎反應調控有關。

關鍵字

過敏性鼻炎 ； 免疫球蛋白E ； 细胞激素 ； 嗜中性白血球

並列摘要

The study is aimed at the chronic invalid of allergic rhinitis. After receiving treatment in acute stadium, the invalid will be prescribed with Ginseng & Astragalus Combination in remission stadium to test the effect of the traditional Chinese herbs done to the immune system.
The invalid were divided into two groups. Invalids in experimental group were provided with Ginseng & Astragalus Combination. Invalids in Control Group were offered Magnolia & Ginger Formula. Both two groups have been receiving the test for two months. Results have shown that significant variation occurred among the invalid in Experimental group after the invalid received treatment. From 3.21±0.08 to 0.56±0.09 (after treatment).We can't see any variation in Control Group. If we look into further the function of the formula, we may discover that Ige in blood serum of experimental Group has used IL-13 to stimulate MNC supernatant fluid to have controlled consistency produced by PGE2 and LTC4. (Fore-treatment vs. after-treatment). The case never happened in control group though. Evidence has shown that Buu jong Yih chih tong can be applied for Allergic rhinitis of remission stadium and to further to ease the pain. Remission may be expected due to the well controlled partial inflammation of the body.

並列關鍵字

Allergic Rhinitis ； Intravenous immunoglobulin E ； Cytokine ； Polymorph nuclear neutrophils