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Cytomegalovirus Pneumonia in a Premature Infant Suffering Chronic Lung Disease: A Case Report

慢性肺疾病早產兒罹患巨細胞病毒肺炎

摘要


住院當中的早產兒一直是感染巨細胞病毒的高危險群,感染的症狀可以是相當的嚴重也可以是沒有症狀。至於極低出生體重(出生體重低於1500公克)且已出現有慢性肺疾病的嬰兒,感染巨細胞病毒肺炎可能會造成呼吸情況的惡化且加重慢性肺疾病的病情,而使得需要更多的氧氣甚至於進一步呼吸器的治療。使用Ganciclovir 來治療非常低出生體重嬰兒的巨細胞病毒感染可以避免慢性肺疾病的惡化,而且可以減少住院天數和呼吸器的需求。住院當中的新生兒感染巨細胞病毒的來源被認為可能是因為輸血感染所造成。新生兒時期因輸血感染巨細胞病毒可以造成相當厲害的症狀。我們報告一個三個多月合併有慢性肺疾病的早產女嬰,因輸血過後感染巨細胞病毒肺炎造成呼吸情況的惡化及加重慢性化肺疾病。經過Ganciclovir四個星期的治療,病人呼吸的情況獲得相當顯著的改善。

並列摘要


Premature infants are at high risk of developing cytomegalovirus (CMV) infection during hospitalization, and the infection may be either clinically apparent or asymptomatic. Acquired CMV pneumonia infection in very low birth weight (VLBW) infants (birth body weight < 1500 gm) with existing chronic lung disease (CLD) will cause respiratory deterioration and worsen the CLD. Ganciclovir treatment for CMV infections in VLBW infants may prevent the worsening of the CLD and the need for more respiratory support and longer hospitalization. Blood transfusions have been implicated as a source of acquired CMV infection in hospitalized neonates. Transfusion-acquired CMV infection can cause significant morbidity and mortality. We present a 3-month-old premature female infant with CLD acquiring CMV pneumonia after blood transfusions, resulting in respiratory deterioration and the CLD worsening. After ganciclivir treatment for 4 weeks, her respiratory condition improved obviously.

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