並列摘要
Airway inflammation is a prominent feature of asthma characterized by infiltration of eosinophils and other inflammatory cells to the airways. Airway production of chemokines, cytokines and adhesion molecules play an important role in the modulation of acute and chronic airway inflammation. Blocking these inflammatory mediators is believed to be of clinical benefit for chronic airway inflammation. Corticosteroids are widely used to treat various immune and inflammatory diseases. The most effective use of corticosteroids is in the treatment of asthma; however, they are ineffective in suppressing the inflammation seen in severe asthma. This article reviews the cells involved in inflammation and immunity associated with asthma. Pro-inflammatory cytokines and chemokines involved in asthma are also discussed. A fully understanding of the relationship between inflammatory cells and their inflammatory mediators may not only provide a useful therapeutic strategy but also an alternative in the treatment of corticosteroid-resistant asthma.
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