Diabetic nephropathy is the most common cause of end-stage renal disease (ESRD) in developed and developing countries. In Taiwan, diabetes mellitus is still increasing as the leading cause of ESRD. Patient survival in diabetics on maintenance dialysis is much lower than that in nondiabetics with ESRD and cardiovascular disease accounted for more than one-half of death. Compared with hemodialysis (HD) and peritoneal dialysis (PD), renal transplantation is associated with increased patient’s long-term survival. For the survival comparison between PD and HD in diabetic patients, most studies have not found a survival difference and the choice of a dialysis modality should be individualized.