Arteriovenous fistulae is the major access of choice for hemodialysis patients. Patients concern the access to be of less pain, no disfigurement and less complications. Buttonhole cannulation uses the dull needle and constant site, which had break the traditional mode of thinking to change the puncture site in each session of dialysis. However, the following reports disclosed that the buttonhole cannulation increasing the infectious risk in local and systemic infections. These adverse reports held back the patients who are intended. Patients and units should be aware that BH is an extremely demanding technique and requires fixed and effective adherence to the protocol. Just like peritoneal dialysis, peritonitis may happen within a period, including exit site infection and systemic bacteremia. It should be an important issue to select patients who suitable for this procedure.