Diabetic kidney disease is the leading cause of chronic kidney disease and end-stage renal disease. This clinical syndrome is characteristic of persistent albuminuria, a relentless decline in glomerular filtration rate (GFR), raised arterial blood pressure, and enhanced cardiovascular morbidity and mortality. Diabetic kidney disease screening should be performed annually, including urinary albumin-to-creatinine ratio and estimated GFR. Kidney biopsy is reserved for atypical presentations.