治療性血漿分離術之原理及應用

Principles and Applications of Therapeutic Apheresis

王婉菁(Wan-Ching Wang) ； 蔡佳璋(Chia-Chang Tsai) ； 王惠芳(Hui-Fang Wang) ； 侯玉琴(Ie-Ching Hu) ； 劉蕙婷(Hui-Ting Liu) ； 黃道民(Tao-Min Huang)

《腎臟與透析》 30卷4期 (2018/12) Pp. 208-213

https://doi.org/10.6340/KD.201812_30(4).0010

摘要

治療性血漿分離術為血液淨化療法，是將患者的血漿從血液中分離後，藉著透析、過濾或吸附作用，將分離出血漿分離後去除有害分子，以達到治療疾病的目的。常用的血漿療法包括血漿置換、血漿灌流術、雙重過濾血漿分離術、血漿透析過濾術與血漿濾過吸附術5種。後4種晚近發展的療法是以儀器精準驅動泵浦方式，利用不同過濾器膜孔大小篩選移除物質，或吸附器進行移除特異性／非特異性物質，進而減少血漿置換的併發症達成治療的目標。

關鍵字

血漿療法 ； 血漿灌流 ； 雙重血漿濾過 ； 血漿透析過濾 ； 血漿濾過吸附

並列摘要

Therapeutic apheresis separates the human plasma from whole blood. By means of this modality, we can effectively remove toxins or unwanted proteins from plasma safely, and even add substances into plasma without complications. The clearance process is achieved with diffusion, hemofiltration, or adsorption. Increasing evidences are accumulating that such treatments are important to treat a variety of human diseases. Besides standard plasmapheresis, plasma perfusion, double filtration plasmapheresis, plasma diafiltration, and coupled plasma filtration and adsorption are among the common procedures we perform in clinical practice. We remove toxins or proteins according to membrane pore sizes, or adsorptive properties to specifically remove unwanted substances, with a hope to modify the disease process, and improve the patient outcomes.

並列關鍵字

therapeutic apheresis ； plasma perfusion ； double filtration plasmapheresis ； plasma diafiltration ； coupled plasma filtration adsorption