腹膜透析之包囊性腹膜硬化症

Encapsulating Peritoneal Sclerosis in Peritoneal Dialysis Patients

李明澤(Ming-Jse Lee) ； 孫樵隱(Chiao-Yin Sun) ； 吳逸文(I-Wen Wu) ； 李進昌(Chin-Chan Lee) ； 陳永昌(Yung-Chang Chen) ； 許恆榮(Heng-Jung Hsu)

《腎臟與透析》 31卷1期 (2019/03) Pp. 30-35

https://doi.org/10.6340/KD.201903_31(1).0007

摘要

此研究回溯性的將基隆長庚紀念醫院1990年8月至2014年4月腹膜透析病人分成有發生包囊性腹膜硬化症（6人）和沒有包囊性腹膜硬化症（對照組）（559人）2組，分析2組各項臨床因子，目的在找出包囊性腹膜硬化症發生的相關因子。透過多變項邏輯斯分析，我們發現只有接受腹膜透析的時間和包囊性腹膜硬化症獨立且顯著相關（p=0.034）。利用receiver operating characteristic curve，我們同時也發現接受腹膜透析8.4年可以良好的預測包囊性腹膜硬化症的發生。

關鍵字

包囊性腹膜硬化症 ； 腹膜透析 ； 末期腎病

並列摘要

Encapsulating peritoneal sclerosis (EPS) is a rare but serious complication of peritoneal dialysis (PD) patients. The purpose of this study was to assess the clinical characteristics of patients with EPS to search for factors useful for EPS early diagnosis. This retrospective study was performed in a single dialysis center in Taiwan between August 1990 and April 2014. Overall, a total of 565 patients were included and the medical records of those patients who had developed EPS (EPS group) and those who had not developed EPS (control group) were collected. We compared several factors between these two groups. In the univariate analysis, EPS was significantly associated with a change of transport state (Δ2) (p = 0.007), duration of PD (p ＜ 0.001), duration of peritonitis treatment (p = 0.001), number of peritonitis episodes (p = 0.002), and fungus related peritonitis (p = 0.031). After multivariate analysis, only the duration of PD was independently significantly associated with EPS (p = 0.034). We also found that duration of peritoneal dialysis of about 8.4 years is the best cut-off point to predict EPS occurrence by receiver operating characteristic curve.

並列關鍵字

encapsulating peritoneal sclerosis ； peritoneal dialysis ； end stage renal disease