The maturation of hemodialysis vascular access could lead sufficient blood flow for hemodialysis, lower the complication, and increase the quality of hemodialysis. The most common reasons of mautation failure of hemodialysis vascular access includes the stenosis of vessels, branches, and the depth from the skin. Most of the issues can be treated by surgical methods. However, some interventions, for examples, the early exercise, antiplatelet drugs, anticoagulants, and other medication, could probably increas the maturation rate and prolong the patency of the vessels. Besides, the cannulation technique is also crucial for maintainace of arterio-venous fistula.