血液透析病患血管通路成熟率及通暢度之藥物治療

Medical Therapy for Improving Maturation and Patency of Hemodialysis Vascular Access

李宗倫(Tsung-Lun Lee) ； 林志慶(Chi-Ching Lin)

《腎臟與透析》 31卷2期 (2019/06) Pp. 63-67

https://doi.org/10.6340/KD.201906_31(2).0004

摘要

動靜脈廔管及動靜脈人工血管為長期血液透析病患必要之血管通路。臨床上常見動靜脈廔管或動靜脈人工血管的狹窄、血栓及成熟失敗。研究指出使用特定藥物治療似乎可降低動靜脈廔管的血栓及功能喪失之機率。高劑量魚油在動靜脈人工血管的血液透析病患也有顯著地降低血栓發生率及心血管事件的風險發生率。找尋其他可有效增加動靜脈廔管及動靜脈人工血管之成熟率及通暢度的藥物具臨床價值，有待更多臨床試驗提供各類藥物之醫學實證。

關鍵字

血液透析 ； 動靜脈廔管 ； 血管通暢度 ； 藥物治療

並列摘要

Arteriovenous fistula and graft are the choices of the types of vascular access for uremic patients who require maintenance hemodialysis. Stenosis, thrombus formation and failure of maturation of both arteriovenous fistula and graft are critical problems commonly seen in the clinical setting. According to previous studies, certain medications, including anti-hypertensive agents and anti-platelets, may reduce the rate of thrombus formation and loss of patency of both arteriovenous fistula and graft. High dosage of fish oil may decrease the incidence rate of thrombus formation and cardiovascular events. To find out possible medications that can effectively improve the maturity and patency of vascular access becomes very important from the clinical viewpoint, thus more clinical trials are needed in the future.

並列關鍵字

hemodialysis ； arteriovenous fistula ； vascular patency ； medical therapy