急性腎損傷與慢性腎臟疾病的連續進程

Acute Kidney Injury-Chronic Kidney Disease Continuum

徐佳鈿(Chia-Tien Hsu) ； 黃俊德(Chun-Te Huang) ； 蔡尚峰(Shang-Feng Tsai) ； 吳明儒(Ming-Ju Wu) ； 陳呈旭(Cheng-Hsu Chen)

《腎臟與透析》 32卷1期 (2020/03) Pp. 17-21

https://doi.org/10.6340/KD.202003_32(1).0004

摘要

慢性腎臟病（chronic kidney disease, CKD）目前被認為是發生急性腎損傷（acute kidney injury, AKI）的一個獨立危險因子。而AKI除了會讓過去沒有腎臟病的病人進展至CKD外，也會加速CKD病人腎功能的退化。病人臨床表現的疾病狀態和預後，和發生腎損傷時有良好還是不良的修復機制有關。因此，我們必須要認知到AKI是造成不良預後的重要危險因子，追蹤那些發生過AKI的病人，也必須建立處理這些病人的策略，發展可行的治療去阻止AKI進展至CKD。

關鍵字

急性腎損傷 ； 慢性腎臟病 ； 疾病連續進程

並列摘要

Chronic kidney disease (CKD) is recognized as an independent risk factor for acute kidney injury (AKI). AKI is an independent risk factor for de novo CKD. AKI also accelerates the progression of CKD. The spectrum of disease state and outcome is associated with the balance of adaptive and maladaptive repair mechanisms to renal insults. We need to identify AKI as a major risk factor for adverse outcome, and provide long-term follow-up to patients with episodes of AKI. Besides, we also need to set up strategies for management of affected patients, and develop therapeutic options to prevent progression from AKI to CKD.

並列關鍵字

acute kidney injury (AKI) ； chronic kidney disease (CKD) ； disease continuum