With the expanding availability of angiography and contrast computed tomography, contrast-associated acute kidney injury (AKI) is one of the leading causes of AKI. Although not completely elucidated, direct and indirect effects are possible pathophysiological mechanisms. Pre-existing chronic kidney disease (CKD) is the strongest risk factor. Contrast-associated AKI is associated with prolonged hospitalization, increased short-term mortality, long-term mortality and accelerated progression of underlying CKD. Minimizing contrast and intravenous hydration via 0.9% saline is the mainstay of prevention.