延展性血液透析術與中截除量透析器

尿毒素分子蓄積，與透析病患的慢性炎症狀態、血管鈣化、繼發性免疫低下、及心血管不良事件的發生率和嚴重程度有關。血液透析對中大分子尿毒素的清除效果較差，而血液透析過濾術雖可增強中大分子的清除，但設備昂貴無法普及。使用新一代中截除量（medium cut-off）透析器進行延展性血液透析術，同時進行擴散和對流作用，可去除高達45,000道爾頓（Daltons）分子量的毒素，比血液透析過濾術能清除的毒素分子量更高，且不增加白蛋白流失，也不增加感染事件的發生率。

關鍵字

延展性血液透析術；中截除量膜；尿毒素分子；內部過濾

並列摘要

The accumulation of uremic toxins in patients receiving dialysis is related to chronic inflammatory state, vascular calcification, secondary immunosuppression, and the incidence and severity of cardiovascular adverse events. The clearance of hemodialysis on middle and large uremic toxin molecules is poor. Although hemodiafiltration (HDF) can enhance the clearance of middle and large molecules, the equipment is expensive and cannot be widely used. A new generation of medium cut-off dialyzer was used for expanded hemodialysis (HDx), a dialytic modality in which diffusion and convection are combined to remove molecules with molecular weight up to 45,000 daltons. The clearance range of HDx exceeds that of HDF and did not increase albumin loss, and the incidence of infectious episodes compared to HDF.

並列關鍵字

expanded hemodialysis (HDx) ； medium cut-off membrane (MCO) ； uremic toxins ； internal filtration

主題瀏覽